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BLOOD AND CEREBROSPINAL FLUID 477 through the reticular system. The wandering cells are spindle shaped or round and usually contain much pigment. In appearance it resembles the human malignant melanosarcoma, though developmentally it is not identical with this type, as it seems to be of mesodermal origin.In a just metamorphosed frog which had carried a strongly growing implant for 22 days a metastatic nodule was found in the connective tissue between the heart and the right thyroid gland. It is made up by pigmented round and spindle shaped cells. The main bulk of the heavily infiltrated reticulum of this little frog, was transplanted, together with the attached liver and most of the intestinal tract, into the body cavity of an adult frog.After fifty days the body of this frog began to swell and at the same time became hard. The animal soon stopped feeding and was dying when it was preserved on the sixty-second day. In the body cavity was found a large tumor which was attached to the peritoneum as well as to the mesentery and was penetrating and destroying the urinary bladder. The closer examination revealed not only a whole network of creeping ramifications through the reticuluni but also numerous metastases in the liver and in the propria of the intestine.The abnormal tissue from the overripe egg, by this double transplantation has attained an age of 92 days, while equally deficient embryos under best care do not live over 2 weeks.