Untolerated or insufficiently effective Therapy in 32 patients (63 eyes) with primary open-angle glaucoma was discontinued and substituted with Timolol, and all patients were followed up over a period of 60 weeks. Timolol was well tolerated in all cases without any local or systemic side effects. Either alone or in combination with other medications Timolol brought about an adequate reduction in intraocular pressure in eyes which hitherto had no longer responded to conventional conservative therapy.

No abstract