Objectives: Screening with cytology decreases cervical cancer burden, but new methods have emerged. We assessed the diagnostic value of electrical impedance spectroscopy (EIS) in the real-world gynecological setting. The study aimed to determine the diagnostic usefulness of EIS used as an adjunct to colposcopies in the diagnosis of high-grade squamous intraepithelial lesions in women with abnormal cytology findings. Material and methods:A cross-sectional, single center, observational study considered 143 women. All were subjected to a colposcopy and EIS with ZedScan. ZedScan-guided or colposcopically-guided biopsies were carried out.Results: Data from 118 women were analyzed. The average age of the included women was 38.29 ± 12.52 years (range: 22-86 years). Overall, 27 had a diagnosis of CIN2+ and above on histopathological examination, 99 had low-grade colposcopy results, 18 had high-grade colposcopy results, and 80 had positive ZedScan examination. No adverse events related to the examination with ZedScan were observed. EIS used as an adjunct to colposcopies showed sensitivity of 96.30% (95% CI: 81.03-99.91) and specificity of 39.56% (95% CI: 29.46-50.36), and accuracy of 52.54% (95% CI: 43.15-61.81). The procedure allowed to detect 11 additional cases with positive histo-pathological result in comparison to colposcopies alone. Conclusions:Colposcopies performed with ZedScan as an adjunct were effective in detecting high-grade cervical lesions. Advantages of ZedScan include real-time result display, no additional diagnostic burden posed on the patient, and good safety profile. Studies on large patient cohorts are needed for further evaluations of this diagnostic procedure and factors which may affect its diagnostic accuracy.

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Background. The impact of lifestyle factors including health-promoting physical activity on complication rate following amniocentesis is unclear. Objectives. To examine the further course of pregnancy in patients undergoing amniocentesis in relation to selected risk factors including the level of health-promoting activity and occupational work on the complication rate after genetic amniocentesis. Material and methods. Medical records from 317 diagnostic amniocenteses were analyzed and 230 procedures carried out on 219 pregnant women were included in the study. Results. The mean maternal age was 34.50 ±5 years (range: 22−47 years). In the patients studied, amniocentesis was performed at 12−24 gestational weeks with a median at 16 gestational weeks (mean: 16. 13 ±2.02 weeks). Overall, 174 amniocenteses (75.6%) did not reveal any genetic disorder while 56 (24.4%) confirmed a genetic disorder. One hundred procedures (43.5%) were followed by at least 1 complication, while 130 procedures (56.5%) were uneventful. The following complications were observed: general pain-37 (16%), fever-5 (2.2%), dizziness-7 (3%), amniotic fluid leakage − 5 (2.2%), vaginal bleeding-3 (1.3%), and fetal death-11 (4.8%). The following lifestyle factors were reported: use of stimulants-12 (5.2%), occupational work-158 (68.7%), commuting-137 (59.6%), and physical activity-62 (27%). Abdominal pain/uterine contractions were significantly more frequent with generalized pain, fever, vaginal bleeding, and physical activity. The presence of dizziness correlated with generalized pain in women who were working and commuting. Working occupationally when pregnant correlated positively with practicing sport. Better newborn condition was significantly correlated with older gestational age and longer sick leave. Conclusions. Physical activity performed by pregnant women after amniocentesis increases the risk of postprocedural complications such as abdominal pain, uterine contractions, dizziness, and syncope. Reducing physical effort 2 weeks after the procedure is recommended. Further studies are warranted.

To evaluate the effect of clinical and demographic factors on the further course of pregnancy and post-procedure complications in healthy and high-risk pregnancies. Materials and Methods: Data of 230 amniocenteses with normal (n=174) and abnormal genetic findings (n=56) were collected retrospectively. Details of birth, neonatal condition, patient characteristics, and post-procedure complications were analysed. Results: The mean maternal age at amniocentesis was 34.50 ± 5 years-old. One hundred (43.48%) were followed by at least one complication. Fetal death occurred after 11 (4.78%) procedures including seven with genetic disorders. There was no significant difference in complication rates between study groups, except for fetal death, which was significantly more common in high-risk pregnancies (p = 0.0017). Abdominal pain correlated with pyrexia and vaginal bleeding. Conclusion: The most severe complications were associated with fetal genetic disorders. The authors conclude that amniocentesis is a safe procedure; however, significant correlations between the incidence of certain complications may be relevant in planning antenatal care.

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