Background: Breast cancer is the most common cancer in women worldwide, in 2012 with nearly 1.7 million new cases were diagnosed. This represents about 12% of all new cancer cases and 25% of all cancers in women. In low and middle-income countries (LMCs), the infrastructure and resources for routine screening mammography are often unavailable.Objective: The objective of this study focused on determining the cytomorphologic patterns of palpable breast lesions in Jima University Specialized Hospital.Methods: A descriptive cross-sectional study was done on breast FNAC medical records. Analysis was done using SPSS version 20. Chi square test was applied to check the significant effect of independent variables on the dependent variables.Result: In this study 735 patients were included and the overall distribution of the lesion was benign neoplastic (51%), non-neoplastic (28%), malignancy (17%) and suspicious (4%). The most common lesions in male were non-neoplastic and in female were benign neoplastic groups. The majority of (49.3%) breast lesions were located in the left breast followed by right breast (43.9%).Conclusion: This study supports the usefulness of cytomorphological diagnostic techniques in the workout of breast lesions, confirms the predominance of benign breast lesions in the young and the occurrence of age independency in malignancy.