Background: Failed induction of labour is defined as when there is failure to generate regular contractions (i.e, every 3 minute) and cervical change after artificial membrane rupture and at least 24 hour of oxytocin use However, the magnitude of failed induction labor in Tigray is not well documented. Therefore, the objective of this study was to assess the magnitude and factors associated with failed induction of labor in the study area. Methods: We conducted institution-based- retrospective record review study of all inductions of labor conducted from April 9, 2017- April 8, 2018(n=380) in Axum St.Mary hospital, Tigray, Ethiopia. Data were entered and analyzed using SPSS version 21 software. The data were cleaned before analysis. Descriptive statistics such as frequency and mean were used to describe the study participants. For the multivariable logistic, binary logistic regression a two tailed p-value <0.05 was performed to show statistical significant. Results: The magnitude of failure of labor induction was found 11.8% (95% CI: 8.7-15.3%). The multivariable binary logistic regression analysis showed that primi-parity (AOR=4.31, 95% CI; 1.22-15.18) and poor Bishop Score (AOR=10.67, 95%CI: 1.31-86.87) were significantly associated with failed induction of labor. Conclusion and recommendation: The failed of labor induction was found high in the study area. The health care providers should assess and document the status of the cervix (using the Bishop score) to determine the probability of success and to select the appropriate method of induction. In addition, they need to consider induction of women with an unfavorable cervix is associated with high failure and a higher caesarean section.