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enantiomeric selectivity occurs as well with cleavage. With A-R u ( T M P )~~+ , twice the cleavage efficiency of the A-form polymer is observed in comparison with A-Ru(TMP)~*+.In summary, A-Ru(TMP);+ has been shown to bind selectively to A-form polynucleotides and in the presence of light to cleave A-form polymers. This chiral probe should be useful to investigate DNA conformational heterogeneity in mapping sites in the A conformation along the helical strand. The role played by DNA secondary structures in protein recognition and in the expression of genetic information may be better understood by using this and other chiral complexes which are targeted specifically to different conformations.(20) Cadet, J.; Teoule, R.

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