Models for the calculation of density, heat capacity, viscosity, and thermal conductivity of amino acid aqueous solutions were proposed. Density, heat capacity, viscosity, and thermal conductivity of pure amino acid liquids were predicted by the Rackett model, Watson model, Heu‐Sheu‐Tu group contribution method, and Sato‐Riedel model, respectively. Mixing rule equations required for the prediction of density, heat capacity, viscosity, and thermal conductivity of amino acid aqueous solutions were suggested. Density, heat capacity, viscosity, and thermal conductivity data of 930, 975, 450, and 167 data points, respectively, for 20 amino acid aqueous solution systems were regressed to determine the most appropriate mixing rule parameters.