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Probiotics have been proposed to ameliorate cognitive impairment and depressive disorder via the gut–brain axis in patients and experimental animal models. However, the beneficial role of probiotics in brain functions of healthy older adults remains unclear. Therefore, a randomized, double-blind, and placebo-controlled multicenter trial was conducted to determine the effects of probiotics on cognition and mood in community-dwelling older adults. Sixty-three healthy elders (≥65 years) consumed either placebo or probiotics containing Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI for 12 weeks. The gut microbiota was analyzed using 16S rRNA sequencing and bioinformatics. Brain functions were measured using the Consortium to Establish a Registry for Alzheimer’s disease, Satisfaction with life scale, stress questionnaire, Geriatric depression scale, and Positive affect and negative affect schedule. Blood brain-derived neurotrophic factor (BDNF) was determined using enzyme-linked immunosorbent assay. Relative abundance of inflammation-causing gut bacteria was significantly reduced at Week 12 in the probiotics group (p < .05). The probiotics group showed greater improvement in mental flexibility test and stress score than the placebo group (p < .05). Contrary to placebo, probiotics significantly increased serum BDNF level (p < .05). Notably, the gut microbes significantly shifted by probiotics (Eubacterium and Clostridiales) showed significant negative correlation with serum BDNF level only in the probiotics group (RS = −0.37, RS = −0.39, p < .05). In conclusion, probiotics promote mental flexibility and alleviate stress in healthy older adults, along with causing changes in gut microbiota. These results provide evidence supporting health-promoting properties of probiotics as a part of healthy diet in the older adults.

Diverse facets of the multifinality configuration in goal-directed behavior are identified and empirically explored. The multifinality construct denotes a motivational structure wherein a single means is linked to several ends. A multifinality configuration maximizes value that a given means promises to deliver while sacrificing expectancy of attainment due to a dilution effect. Several phenomena implied by multifinality theory are investigated, including an unconscious quest for multifinal means, the constraints that such quest imposes on means to a focal goal, and structural conditions under which an activity may be experienced as intrinsically motivated. Multifinality phenomena appear in numerous domains of social cognition, and the present theory offers a novel perspective on classic motivational effects.

This research examines the possibility that people's choices in the service of an explicit focal goal may also reflect their tendency to fulfill implicit background goals and in that sense are multifinal. We carried out 5 experimental studies to investigate this notion. In Experiment 1, a primed implicit goal affected individuals' choices even when those avowedly served an explicit "focal" goal. Experiment 2 replicated this finding with a different type of implicit goals. Experiment 3 found that primed implicit goals had no effect on choices where the options that served them undermined the explicit goal. Experiment 4 found that a primed implicit goal served by a multifinal option does not privilege it over a unifinal option if that goal had been already attained by a different means. Finally, Experiment 5, via 3 types of control groups, showed that choices were affected by both the explicit and implicit goals in isolation, and they shifted toward multifinality when these goals were conjointly present. The discussion considers the integrative potential of the multifinality framework and its implications for a variety of phenomena in the domain of motivated cognition.