Objectives: The study aims to focus on the ergonomic risks on mental agony and musculoskeletal pain (MSP) as well as discuss the potential solutions for minimizing the negative consequences of occupational risks among Thai informal workers. Methods: The analysis sample comprised of 805 informal workers in Thailand. Research instruments were consisted of an interview questionnaire and the ergonomic checklist. Results: MSP location was highest distributed to upper back (86.8%). Only 11.2% and 2.9% of the participants had no sign of anxiety and burnout. Poor work methods were identified as the most frequently exposed ergonomic risk. Burnout, anxiety, and workstation design were the significant risks impacting the severity of MSP. Physical environmental was the significant risk for anxiety, while physical environment and work methods were the significant risks for burnout.Conclusions: Interdisciplinary assessments and multi-level/sector approaches should be taken into account in planning the community health services for preventing occupational risks and MSP.