Based on an analogy with adrenergic j-receptor stimulants and their antagonists, several aminoethylimidazo[l,2nlpyridines and -imidazo[1.5-aJpyridines including their tetrahvdro derivatives were synthesized as potential histamine Ha-receptor antagonists. Neither agonist nor antagonist activity at H2 receptors was detected. 2-(2-Aminoethyl)imidazo[l,2-a]pyridines were, however, found to be moderately active Hi-receptor agonists.
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