List Categories and Criteria (Version 3.1) (IUCN, 2012a); (2) Guidelines for Using the IUCN Red List Categories and Criteria (Version 8.1) (IUCN Standards and Petitions Subcommittee, 2010); (3) Guidelines for Application of IUCN Red List Criteria at Regional and National Levels (Version 4.0) (IUCN, 2012b)。 本次评估使用了以下IUCN等级: 灭绝(Extinct, EX)、野外灭绝(Extinct in the Wild, EW)、区域灭绝

Allisartan isoproxil (AI) is a blocker of the angiotensin II type 1 receptor. We evaluated the safety and pharmacokinetics of single-and multiple-dose AI in healthy Chinese individuals. Participants were assigned to receive AI or placebo. Plasma concentration of EXP3174 (carboxylic acid derivative) was measured using liquid chromatography-tandem mass spectrometry. Pharmacokinetic parameters were determined by noncompartmental methods. Twelve subjects were enrolled, and the ratio of men to women was 5:1. Main pharmacokinetic parameters of EXP3174 after single and multiple doses of AI were a mean maximum concentration in plasma (C max ) of 2242 ± 1037 ng/mL and median time to reach C max (T max ) of 3.5 hours (2.5-8 hours). The median T max, at steady state was 4.0 hours (1.5-8 hours). The mean C max at steady state (C max, SS ) was 2047 ± 1050 ng/mL. In terms of EXP3174, there was no significant difference in the C max, SS , area under the curve from time zero to 24 hours of quantifiable concentration at steady state (AUC 0-24 SS ), and AUC 0-72 after multiple doses of AI. Serious adverse events did not occur. These data suggest that AI is safe and well tolerated in healthy Chinese individuals at a single dose of 480 or 480 mg once daily for 7 days.

The risk of transmission of CMV from mother to fetus in early pregnancy is very high and potential CMV carriers may transmit CMV to their fetus in early pregnancy.