Severe dental caries is a multimicrobial infectious disease that is strongly induced by the cross-kingdom biofilm formed by S. mutans and C. albicans . This study aimed to investigate the potential of caffeic acid phenethyl ester (CAPE) as a natural product in the prevention of severe caries.

AimTo evaluate the effectiveness and complications of the cushioned grind‐out technique. The primary outcome was endo‐sinus bone gain (ESBG), while secondary outcomes included the Schneiderian membrane perforation rate and mid‐ to long‐term implant survival.Materials and MethodsIn this retrospective study, we compared the cushioned grind‐out technique with the classic osteotome technique, establishing statistical models to assess ESBG, membrane perforation rate and implant survival rate.ResultsA total of 259 patients and 340 implants were included. The mean ESBG was 5.31 mm for the cushioned grind‐out group and 4.64 mm for the osteotome group. Multivariable regression analysis revealed that the cushioned grind‐out technique significantly facilitated ESBG (p = .028). Nineteen preparation sites experienced membrane perforation, with rates of 5.5% and 6.4% for the cushioned grind‐out and osteotome groups, respectively. However, the difference was not statistically significant (p = .920). Additionally, the cumulative survival rate of the implants for 7 years was 95.2% and 91.4%, respectively, with the surgical technique not significantly influencing the results.ConclusionsWith 6 months to 7 years of post‐prosthetic restoration review data, our findings show that the cushioned grind‐out technique facilitates a higher ESBG, with no significant difference in membrane perforation or implant failure rate.

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Objectives This study aimed to evaluate the effects of the cushioned grind‐out technique transcrestal sinus floor elevation for simultaneous implant placement with ≤4 mm of residual bone height (RBH). Materials and Methods This was a retrospective propensity score matching (PSM) study. Five PSM analyses included the confounding variables of Schneiderian membrane perforation, early and late implant failure, and peri‐implant apical and marginal bone resorption. After PSM, we compared the difference in five aspects between the RBH ≤ 4 and >4 mm groups. Results A total of 214 patients with 306 implants were included in this study. After PSM, the generalized linear mixed model (GLMM) indicated that RBH ≤ 4 mm had no significantly higher risk of Schneiderian membrane perforation and early and late implant failure (p = .897, p = .140, p = .991, respectively). The implant cumulative 7‐year survival rate of the RBH ≤ 4 and >4 mm groups was 95.5% and 93.9%, respectively (log‐rank test: p = .900). Within at least 40 cases per group after PSM, two multivariate GLMMs indicated that RBH ≤ 4 mm could not be identified as the promotive factor of bone resorption of either endo‐sinus bone gain or crest bone level (RBH × time interaction p = .850, p = .698, respectively). Conclusions Within the limitations, 3 months to 7 years of post‐prosthetic restoration review data indicated an acceptable mid‐term survival and success rate of applying the cushioned grind‐out technique in RBH ≤ 4 mm cases.

Spinal glioblastoma multiforme (GBM) that originates from the conus medullaris is rare as only 28 cases have been reported. It is highly aggressive and usually initially presents with low back pain, sensory and motor impairment of the lower extremities, and bladder dysfunction. We herein report a unique case of GBM in the conus medullaris with leptomeningeal dissemination that initially presented with increased intracranial pressure without hydrocephalus. The patient was first diagnosed with tuberculous meningitis and received antituberculosis therapy, but the symptoms did not resolve and even worsened. Subsequent radiological imaging clearly disclosed an intramedullary lesion at the T12 level with the progression of leptomeningeal enhancement. Subtotal resection of the intramedullary lesion was performed, and pathological examination revealed the presence of GBM. To our knowledge, our case was the first with holocordal and intracranial leptomeningeal dissemination that initially presented with intracranial hypertension in the absence of hydrocephalus. Awareness of this unusually lethal condition is significant for proper diagnosis, timely treatment, and consideration of clinical prognosis.