The quality of bone mineral was preserved after treatment with strontium ranelate, supporting the safety of this agent at the bone tissue level.

Tailoring the physical features and the porous network architecture of silica-based hyperpolarizing solids containing TEMPO radicals, known as HYPSO (hybrid polarizing solids), enabled unprecedented performance of dissolution dynamic nuclear polarization (d-DNP). High polarization values up to P( H)=99 % were reached for samples impregnated with a mixture of H O/D O and loaded in a 6.7 T polarizer at temperatures around 1.2 K. These HYPSO materials combine the best performance of homogeneous DNP formulations with the advantages of solid polarizing matrices, which provide hyperpolarized solutions free of any-potentially toxic-additives (radicals and glass-forming agents). The hyperpolarized solutions can be expelled from the porous solids, filtered, and rapidly transferred either to a nuclear magnetic resonance (NMR) spectrometer or to a magnetic resonance imaging (MRI) system.

Tailoring the physical features and the porous network architecture of silica-based hyperpolarizing solids containing TEMPO radicals,k nowna sH YPSO (hybrid polarizing solids), enabled unprecedented performance of dissolution dynamic nuclear polarization (d-DNP). High polarization values up to P( 1 H) = 99 %w ere reached for samples impregnated with am ixture of H 2 O/D 2 Oa nd loaded in a6 .7 Tp olarizer at temperatures around 1.2 K. These HYPSO materials combine the best performance of homogeneous DNP formulations with the advantages of solid polarizing matrices,whichprovidehyperpolarized solutions free of any-potentially toxic-additives (radicals and glass-forming agents). The hyperpolarized solutions can be expelled from the porous solids,f iltered, and rapidly transferred either to an uclear magnetic resonance (NMR) spectrometer or to amagnetic resonance imaging (MRI) system.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

Objective: To investigate interactions between strontium (Sr) and bone mineral and its effects on mineralization in osteoporotic women treated long-term with Sr ranelate (SrRan). Design: In this study, 34 iliac bone biopsies were analyzed after 2, 12, 24, 36, 48, and 60 months of treatment with SrRan. Methods: Sr global distribution was analyzed by X-ray cartography and the percentage of bone area containing Sr was calculated in the bone samples. The focal distribution of Sr in all bone samples was investigated by X-ray microanalysis. The degree of mineralization was assessed by quantitative microradiography. Results: Absent from old bone formed before the beginning of treatment, Sr was exclusively present in bone formed during this treatment with a much higher focal Sr content in new bone structural units than in old ones. A progressive increase in the extent of areas containing Sr was observed during treatment. The focal bone Sr content in recently formed bone was constant over treatment. Secondary mineralization was maintained at a normal level during treatment. Conclusion: Thus, the quality of bone mineralization (density and heterogeneity at tissue level) was preserved after a long-term treatment with SrRan.

Asphaltenes are considered the most problematic components of heavy oils because they can self-aggregate which leads to precipitation and causes various problems during oil recovery, transportation and refining. The contribution of the porphyrins present in asphaltenes to the aggregation cannot be studied by direct elementary analysis techniques since in this form, the porphyrins are complexed with metals. Thus, gel permeation chromatography inductively coupled plasma-mass spectrometry (GPC-ICP MS) has been used in previous studies. The results