No abstract

Background: Dyslipidemia contributes to the development and progression of cardiovascular disease. The objective of this study was to investigate the association between the non-high-density lipoprotein-cholesterol-to-high-density lipoprotein-cholesterol (non-HDL-c/HDL-c) ratio and mortality for patients with sepsis.Methods: Using data from the eICU Collaborative Research Database (eICU-CRD) with high granularity data for over 200,000 admissions to ICUs monitored by eICU Programs across the United States. We identified 1680 patients with sepsis. All-cause mortality within 30-days after the date of visit to the ICU. We estimated the risk of mortality using multivariable logistic-regression model.Result: There were 115 deaths (6.85%). The probability of mortality decreased when the nonHDLc/HDLc ratio lower than the turning point ( <3.58) with a adjusted odds ratio (OR) of 0.75 (95% CI: 0.61–0.94, P=0.011) for every 1 increment of nonHDLc/HDLc ratio. With the per-SD increase in the nonHDLc/HDLc ratio, the OR for mortality was 0.36 (95% CI: 0.16–0.79, P=0.011) when nonHDLc/HDLc ratio was <3.58, while the OR was 1.56 (95% CI: 1.29–1.88, P<0.001) when nonHDLc/HDLc ratio was ≥ 3.58.Conclusion: Higher nonHDLc/HDLc ratio, even at a low level, was associated with a higher risk of 30-day mortality for patients with sepsis. The probability of mortality rose rapidly when the nonHDLc/HDLc ratio higher than the turning point (may at 3.58).