Our purpose is to elucidate the roles of some molecules and DNA methylation in cerebellar development. Immunocytochemistry was performed to investigate the expression of activated Notch1 and Sonic Hedgehog (Shh), as well as DNA methylation during cerebellar development at various ages. Notch1 could be expressed in neural stem cells, newborn neurons and Purkinje cells during cerebellar development. However, Shh could be expressed mainly in developing radial glia or Bergmann cells specifically.

No abstract