A collection of 1159 enterococcal isolates from five Chinese hospitals were screened for the presence of the novel oxazolidinone resistance gene optrA, which was found in 34 (2.9%) isolates. Pulsed-field gel electrophoresis (PFGE) typing of 29 optrA-carrying Enterococcus faecalis isolates revealed 25 PFGE patterns, and multilocus sequence typing yielded 20 sequence types. Routine surveillance of optrA-positive enterococci in hospitals should be conducted to monitor and counteract their further dissemination. The data of this study may be used as a baseline from which to judge future decreases or increases in optrA-positive enterococci.

VAC therapy represents a good clinical efficacy in treating osteomyelitis; it can promote the granulation tissue formation, bacterial clearance, and reduce the needs for tissue transfer and muscle flaps in patients. In addition, it could be used as an adjuvant for the eradication of osteomyelitis and improving soft-tissue management, it may be more suitable for treating osteomyelitis with soft-tissue problems.

Background: Nutrition is an important prevention in old patients with COVID-19. However, in China, there are few studies on the correlation between nutrition and COVID-19. Methods: A total of 148 hospitalized to 101] years old) patients were enrolled in this study. The information of demographic, biochemical results, vaccination doses, types of COVID-19, PCR test negative conversion time, and scores of Mini Nutritional Assessment Short Form (MNA-SF) for evaluating nutritional status were recorded. We first explored the relationships between MNA-SF performance and the severities of COVID-19 in the groups with non-vaccinated, vaccinated, and all the patients using multivariable ordinal logistic regression. Further, we explored the relationships between performance of MNA-SF and the time of negative conversion of PCR in the groups with non-vaccinated, vaccinated, and all the patients using COX proportional hazards survival regression. Results: Group of patients with malnutrition or at risk of malnutrition group was associated with older of the age, those who had not been vaccinated, in fewer people who were asymptomatic type and in more people who showed longer of the negative conversion time of PCR, lower of the BMI, and the lower of the hemoglobin level. Each additional increase of one point of MNA-SF was associated with a 17% decrease in the odds of a worse type of COVID-19 in all patients, and the significant result exists in non-vaccinated patients. One point increase of MNA-SF was associated with increased 11% of hazard ratios of turning negative of PCR and wellnourished group was associated with increased 46% of hazard ratio of turning negative of PCR. Conclusion: Higher nutrition is associated with less severity of COVID-19, especially in the non-vaccinated group. Higher nutrition is also associated with shorter time of turning negative of PCR in non-ICU COVID-19 patients.

None of the authors have any financial interest to declare.

Background The pandemic of COVID-19 had posed challenges in every aspect of the people’s life. COVID-19 had affected all age groups in both previously healthy individuals and those with chronic disease including IBD. This study aimed to investigate the occurrence and factors associated with psychosocioeconomical and medical changes in patients with IBD during the COVID-19 pandemic and post-pandemicperiod in China. Methods The survey questionnaires were sent to the patients with IBD in China including epicentres and outside. Bivariate analyses and logistic regression models were used to analysis associations between IBD and various demographic, disease factors, and patient-reported outcomes including working conditions, income, anxiety, stress, and sadness. Results Of the 2277 respondents, 144 (6.3%) respondents were from Hubei province which was the epicenter of COVID-19 in China. Multivariable regression demonstrated that patients had part-time work (odds ratio [OR]: 4.28; 95% confidence interval [CI]: 2.48-7.36; P<0.001) or those had middle education level (high school graduate and bachelor’s degree) (OR:7.28; 95%CI: 3.58-14.81; P<0.001) were more likely to have reduced income compared with those had full-time work or less than high school education level. In addition, female (OR: 1.41; 95%CI: 1.16-1.71; P= 0.01) patients were at higher risk of having an anxiety, stress and sadness disorder. While un-married patients (OR: 0.76; 95% CI: 0.63-0.91; P=0.003) patients were less likely to have mood changes. Moreover, IBD patients with active disease (OR: 4.79; 95% CI: 3.87-5.91; P<0.001) were at higher risk of IBD medication changes. Conclusion The results from this large survey demonstrated that the COVID-19 pandemic affected the patients with IBD financially, psychosocially, and medically. Our findings highlighted the importance of screening for psychosocioeconomic and medical changes in patients with IBD, with particular attention to those of female sex, have part-time work, and active disease. Our IBD community needs to develop effective and feasible strategies to deal with current and future challenges such as a viral pandemic.