Elevated ground-level ozone (O 3 ), reflecting atmospheric oxidative capacity, are of increasing concern. High levels of total oxidants (O x = O 3 + NO 2 ) have been persistently observed as a feature of Beijing's air pollution. Beijing is a well-known megacity requiring the enforcement of stringent air quality controls as rapid economic growth continues. To evaluate the effect of air quality controls in recent years, ground-based on-line measurements at an urban site were conducted in summer and the variations in O 3 with simultaneous changes in NO x and volatile organic compounds (VOCs) between 2005 and 2011 were analyzed. Both NO x and total VOCs in Beijing decreased over the study period, 1.4 ppbv yr −1 and 1.6 ppbv yr −1 , respectively. However, VOCs reactivity, in terms of OH loss rate, showed an indistinct statistical trend due to unsteady variations from naturally emitted isoprene, though some anthropogenic species showed decreasing trends, such as pentane, benzene and toluene. Meanwhile, daytime average O 3 increased rapidly at an annual rate of 2.6 ppbv yr −1 , around 5 % yr −1 between 2005 and 2011. Considering the influence of NO titration effect and elevated regional ozone background in the North China Plain (NCP), the main reason for such an increase in oxidants was subject to "local" photochemistry. A simplified model was used to evaluate the effect of changes in the levels of ozone precursors on ozone production. We found that between 2001 and 2006, the production rate of total oxidants, P (O x ) increased rapidly due to increased VOC levels and decreasing NO 2 , while from 2006 to 2011 P (O x ) re-mained high, though decreased slightly as a consequence of the decrease in both VOC reactivity (−5 % yr −1 ) and NO x (−4 % yr −1 ). Observations have shown that Beijing's efforts to control air pollution were somehow effective in cutting ozone precursors, but still left higher ground-level ozone. We surmised that it resulted from potential contributions from OVOCs and regional transport near Beijing. Therefore, Beijing needs deeper cooperation with adjacent provinces to control ozone pollution together. To impel this kind of joint prevention and control program, ground-level ozone should become a mandatory index for air quality management, and a faster reduction of VOCs, especially reactive VOCs, in urban areas, should coordinate with national NO x emission control programs.

Human papillomavirus (HPV) is known to be associated with several types of human cancer, including cervical, vulvar, vaginal, penile, anal, and head-and-neck cancers. Among these cancers, HPV-associated head-and-neck cancers, inclusive of oropharyngeal squamous cell carcinoma (OSCC) and oral cavity squamous cell carcinomas (OCSCC), have recently risen dramatically in men under 50 years old. Within 20 years, the percentage of HPV-positive OSCC in total OSCC went from less than 20% to more than 70% in the United States and some European countries. This article reviews the incidence trend and pathogenesis of HPV-associated head-and-neck cancers as well as current treatment modalities for the disease.

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Colorectal cancer (CRC), one of the common malignant cancers in the world, is caused by accumulated alterations of genetic and epigenetic factors over a long period of time. Along with that protein-coding genes being identified as oncogenes or tumor suppressors in CRC, a number of lncRNAs have also been found to be associated with CRC. Considering the important regulatory role of lncRNAs, the first goal of this study was to identify CRC-associated lncRNAs from a public database. One such lncRNA, LINC00472, was verified to be downregulated in CRC cell lines and cancer tissues compared with adjacent tissues. In addition, the down-regulation of LINC00472 seemed to be caused by DNA hypermethylation at its promoter region. Furthermore, the expression of LINC00472 and DNA methylation of promoter were significantly correlated with clinicopathological features. And DNA hypermethylation of LINC00472 may serve as a better diagnostic biomarker than its expression for CRC. Finally, we predicted the functions of LINC00472 and constructed a regulatory network and found LINC00472 may be involved in cell cycle and cell proliferation processes. Our results may provide a clue to further research into the function and regulatory mechanism of LINC00472 in CRC.

Single-dose Jintrolong injection was well tolerated in healthy adult subjects, and the maximum tolerable dose was no lower than 0.8 mg/kg. Jintrolong was long-acting with the potential for weekly administration.