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Considering the effect of axial loads in the rail, this study presents a hybrid approach to investigate the dynamic responses of vehicle-track-foundation system. In this model, the vehicle is taken as a multi-rigid-body subsystem, and the ballastless track is simulated as Euler beam supported by two-layer elastic foundation. The coupled dynamic equations of system with axial loads are derived based on D’Alembert’s and Hamilton’s principles. The proposed methodology is validated through the real example to be numerically analyzed. The results show that the tensile force in rail is tending to have the amplitude of vibration decrease, and the compress force would bring the amplitude of vibration going up. So a rational axial loading is necessary to suppress the vibration of vehicle-track-foundation system when the car moving at a high speed.