This study provides evidence of a specific therapeutic effect of treadmill training on Parkinsonian gait and balance. Walking on a treadmill may be used as an easy, effective and accessible way to improve the stride length and balance in PD patients.

Gait disturbances are one of the principal and most incapacitating symptoms of Parkinson’s disease (PD). In addition, walking economy is impaired in PD patients and could contribute to excess fatigue in this population. An important number of studies have shown that treadmill training can improve kinematic parameters in PD patients. However, the effects of treadmill and overground walking on the walking economy remain unknown. The goal of this study was to explore the walking economy changes in response to a treadmill and an overground training program, as well as the differences in the walking economy during treadmill and overground walking. Twenty-two mild PD patients were randomly assigned to a treadmill or overground training group. The training program consisted of 5 weeks (3 sessions/week). We evaluated the energy expenditure of overground walking, before and after each of the training programs. The energy expenditure of treadmill walking (before the program) was also evaluated. The treadmill, but not the overground training program, lead to an improvement in the walking economy (the rate of oxygen consumed per distance during overground walking at a preferred speed) in PD patients. In addition, walking on a treadmill required more energy expenditure compared with overground walking at the same speed. This study provides evidence that in mild PD patients, treadmill training is more beneficial compared with that of walking overground, leading to a greater improvement in the walking economy. This finding is of clinical importance for the therapeutic administration of exercise in PD.

The aerodynamic loads generated in a wing are critical in its structural design. When multi-element wings with wingtip devices are selected, it is essential to identify and to quantify their structural behaviour to avoid undesirable deformations which degrade the aerodynamic performance. This research investigates these questions using numerical methods (Computational Fluid Dynamics and Finite Elements Analysis), employing exhaustive validation methods to ensure the accuracy of the results and to assess their uncertainty. Firstly, a thorough investigation of four baseline configurations is carried out, employing Reynolds Averaged Navier–Stokes equations and the k-ω SST (Shear Stress Transport) turbulence model to analyse and quantify the most important aerodynamic and structural parameters. Several structural configurations are analysed, including different materials (metal alloys and two designed fibre-reinforced composites). A 2022 front wing is designed based on a bidimensional three-element wing adapted to the 2022 FIA Formula One regulations and its structural components are selected based on a sensitivity analysis of the previous results. The outcome is a high-rigidity-weight wing which satisfies the technical regulations and lies under the maximum deformation established before the analysis. Additionally, the superposition principle is proven to be an excellent method to carry out high-performance structural designs.