Abstract. Numerous studies have illustrated the relationship between social support and subjective well-being, the intermediary between this has not been examined detailedly. The article aims to explore the college students' subjective well-being on the background of cultural integration and social development, as well as the relationship between social support and subjective well-being: mediator roles of self-esteem and self-efficacy. The results indicated that: (1) Social support has positive effect on subjective well-being; (2) Self-esteem plays a partly intermediary role on the relationship between social support and subjective well-being; (3) Self-efficacy plays a partly intermediary role on the relationship between social support and subjective well-being.