No abstract

Alkali burns of the cornea may lead to permanent visual impairment or complete blindness. In the current study, the role of microRNA 296 (miR-296) was explored in mouse corneal neovascularization induced by alkali burns. An alkali burn model in Balb/c mice was developed to study chemical corneal injuries. The expression of the miR-296 gene was measured by reverse-transcription-quantitative polymerase chain reaction. Fibroblast growth factor 23 (FGF23) protein expression was measured by western blot analysis. Possible impacted pathways were analyzed by Kyoto Encyclopedia of Genes and Genomes pathway analysis. miR-296 gene expression was examined following chemical corneal injury and it was demonstrated that different topical eye medications decreased miR-296 gene expression. miR-296 may participate in cytokine-cytokine receptor interaction pathways to influence corneal inflammatory responses. It was also revealed that FGF23 was expressed following chemical corneal injury and that different treatments with topical eye drops decreased its expression. miR-296 is a novel molecular modulator for alkali burns in the mouse cornea.

No abstract

Suspended sediment in the water body of rivers flowing into the sea is of great significance to the accumulation process in river basins and change pattern of landforms. In particular, small and medium rivers entering the sea in mountainous areas exhibit the characteristics of both mountains and streams, and the suspended sediment concentration (SSC) greatly contributes to the formation and evolution of deltas. However, scholars rarely give attention to the factors influencing changes in the SSC in small- and medium-sized mountainous rivers, and few studies have examined SSC changes in small- and medium-sized mountainous rivers. Here, based on daily SSC and flow data obtained at the Bobai Station and Changle Station, the percentile method and regression analysis method are employed to analyse the changes in SSC from the Nanliu River to the Beibu Gulf and possible influencing factors. The main research results indicate that 1) the SSC in river water bodies from 1965 to 2020 generally reveals a downwards trend, with significant annual variations. Specifically, the overall trend can be divided into three stages: 1) the SSC is the highest from 1965 to 1971, and the mean yearly SSC reaches 0.25 kg/m3; 2) the SSC is relatively high from 1972 to 2006, and the mean yearly SSC reaches 0.16 kg/m3; and 3) the SSC is the lowest from 2007 to 2020, and the mean yearly SSC reaches 0.11 kg/m3 2) High values of the SSC are mainly concentrated in the flood season, and low SSC values mostly occur in the dry season. The monthly average SSC in the flood season from April to September and the dry season from October to March exhibits the characteristics of a decrease in the flood season and an increase in the dry season. Moreover, the peak SSC value in the watershed obviously occurs out of sync with the peak flow value. Generally, the former precedes the latter. 3) The curve of the flow rate-sediment ratio is an irregular clockwise rhombus. Moreover, the impact of tropical cyclones, land cover changes, regional GDP per capita, and engineering construction are crucial reasons for the observed variations in the SSC in the Nanliu River Basin. In this paper, the obtained research results provide an important guiding significance for the planning and management of water and sediment resources in the Nanliu River and offer a reference for hydrological planning of other river basins discharging into the sea.

To observe the effect of micro-conjunctival auto grafting combined with amniotic mem- brane transplantation on the postoperative recurrence, complications and ocular surface symptoms among patients with recurrent pterygium.