Polycomb group (PcG) complexes modify histones to silence tumor suppressor genes, which exhibit an important function in tumorigenesis and progression. The chromobox (Cbx) protein family is a critical component of PcG-mediated repression. Cbx2, a member of the Cbx protein family, is hypothesized to exhibit a vital role in breast cancer. In the present study, immunohistochemical analysis using tissue microarrays was performed to determine the levels of Cbx2 protein expression in breast cancer. The association between Cbx2 expression and the clinical features and prognosis of 455 breast cancer patients was analyzed. In addition, the efficacy of Taxol was evaluated by comparing the survival of patients with high or low Cbx2 expression. The results revealed that Cbx2 expression was higher in cancer tissues compared with adjacent normal tissues. Furthermore, high Cbx2 expression was significantly associated with large tumor size, lymph node metastasis, high TNM stage and positive human epidermal growth factor receptor-2 (HER-2) status. Patients with high Cbx2 expression also exhibited a shorter mean overall survival (OS) time (74.37 months) compared with patients with low Cbx2 expression (77.37 months). Univariate analysis indicated that high Cbx2 expression increased the risk of mortality by 1.826-fold compared with low Cbx2 expression [hazard ratio (HR), 1.826; 95% confidence interval (CI), 1.069–3.116; P=0.027]. Among patients with high Cbx2 expression, the mean OS time of individuals treated with Taxol (71.01 months) was lower compared with patients that had not received Taxol treatment (78.43 months; log-rank test statistic, 13.03; P<0.001). However, no significant difference in OS time was identified in the low expression group. The results of the current study revealed that Cbx2 may present a novel biomarker for predicting the prognosis of breast cancer patients. Cbx2 may also represent a potential target for treatment due to its important function in Taxol treatment responses.

K-criterion that is used to boundary line and brittle fracture is presented when the size of plastic zone around crack-tip is less than that of adaptive zone of K-criterion by comparison adaptive zone of K-criterion with plastic zone around crack-tip in this paper. Finally numerical examples are given to illustrate the applications of the present method by comparison with other methods.

In view of the high precision requirements of the more complex stamping parts of the springback law, this paper put forward a rebound closed loop control system model based on the improved Fourier transform. First of all, starting from the product model, it use the method finite element analysis and the forming process parameter optimization for the initial mold design, and then to measure the mould and stamping products and assess the springback error. Finally, eliminating the springback error through two iterative loops to complete the final mold fixed compensation. Experiments show that the system can complete the mould shape correction effectively by using the model and realize the springback compensation of complex stamping parts.

Diffraction grating is a kind of very sophisticated optical element, It is usually used diamond ruled grating. Edge radius is one of the important parameters of diamond ruled grating, the effect of the edge radius to diffraction efficiency and ruled depth is analyzed by the theoretical calculation and finite element analysis in this paper. Get the influence law of diffraction efficiency, ruled depth and the ruling force, which has provided the theory basis for correctly precision edge radius.

At present, the performance evaluation of thermal spraying coating mainly depends on experimental test and numerical calculation, but due to the limitation of error and algorithm, neither of the two algorithms can effectively satisfy the effective evaluation of thermal spraying performance. In this paper, taking WC/Co coating as an example, a new method for calculating the performance parameters of thermal spraying coatings is proposed, that is, the finite element model and the analysis model of coating parameters are established for the microstructure of the coatings under different magnification, respectively. By calculating the basic performance parameters of the coatings, the macro performance parameters of the thermal spraying coatings are obtained, so that the performance of the coatings can be evaluated.