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Background The transformation of the medical pattern into the biological-sociological and psychological medical model has made the importance of humanities in medical education increasingly prominent. This study analyzes the effectiveness and importance of integrating humanistic qualities into clinical teaching in dermatology. Methods During July 2016 to August 2020, interns training in Departments of Dermatology, Zhujiang Hospital, 200, according to the order of student number of grouping experimental group and control group, four groups of 50, respectively, the control group of interns on conventional teaching in practice stage, while the experimental group of intern trainee phase combination of humanity quality education in teaching, compared two groups of interns teaching and learning effects. Results Medical history collection/interrogation techniques, practical operation and observation of history writing scores of the experimental group of interns were significantly higher than those of the control group, and the experimental group of interns humanistic quality education related indicators were significantly better than the control group (P <0.05). Conclusions The results put forward some countermeasures and suggestions for cultivating and optimizing the humanistic care spirit of medical students.