Peptide transporter 2 (PepT2) in mammals plays essential roles in the reabsorption and conservation of peptide-bound amino acids in the kidney and in maintaining neuropeptide homeostasis in the brain. It is also of significant medical and pharmacological significance in the absorption and disposing of peptide-like drugs, including angiotensin-converting enzyme inhibitors, β-lactam antibiotics and antiviral prodrugs. Understanding the structure, function and regulation of PepT2 is of emerging interest in nutrition, medical and pharmacological research. In this review, we provide a comprehensive overview of the structure, substrate preferences and localization of PepT2 in mammals. As PepT2 is expressed in various organs, its function in the liver, kidney, brain, heart, lung and mammary gland has also been addressed. Finally, the regulatory factors that affect the expression and function of PepT2, such as transcriptional activation and posttranslational modification, are also discussed.
A meta‐learning based method for finger vein recognition with few samples is proposed to overcome the problem of low recognition accuracy caused by the small number and variety of finger vein samples as well as fuzzy vein lines. The method is based on meta‐learning, incorporating multiscale features, and using the idea of residual networks to join meta‐learning to improve the recognition accuracy of finger vein images with few samples; to further improve its recognition ability, a differential map is constructed in the form of a differential between the finger vein image of singular value decomposition and finger vein image. We are the first to apply meta‐learning to the field of finger vein recognition, to our knowledge, and the experiments show that this approach is superior, with recognition accuracy of up to 99.13% for finger vein datasets with few‐shot samples.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.