(2015) Selective targeting of the IL23 pathway: Generation and characterization of a novel high-affinity humanized anti-IL23A antibody, mAbs, 7:4, 778-791, DOI: 10.1080DOI: 10. /19420862.2015 To link to this article: https://doi.org/10. 1080/19420862.2015 Herein, we describe the generation and characterization of BI 655066, a novel, highly potent neutralizing antiinterleukin-23 (IL23) monoclonal antibody in clinical development for autoimmune conditions, including psoriasis and Crohn's disease. IL23 is a key driver of the differentiation, maintenance, and activity of a number of immune cell subsets, including T helper 17 (Th17) cells, which are believed to mediate the pathogenesis of several immunemediated disorders. Thus, IL23 neutralization is an attractive therapeutic approach. Designing an antibody for clinical activity and convenience for the patient requires certain properties, such as high affinity, specificity, and solubility. These properties were achieved by directed design of the immunization, lead identification, and humanization procedures. Favorable substance and pharmacokinetic properties were established by biophysical assessments and studies in cynomolgus monkeys.

Recent Experimental Advanced Superconducting Tokamak (EAST) experiments have successfully demonstrated a long-pulse steady-state scenario with improved plasma performance through integrated operation since the last IAEA FEC in 2016. A discharge with a duration over 100 s using pure radio frequency (RF) power heating and current drive has been obtained with the required characteristics for future long-pulse tokamak reactors such as good energy confinement quality (H98y2 ~ 1.1) with electron internal transport barrier inside ρ  <  0.4, small ELMs (frequency ~100–200 Hz), and good control of impurity and heat exhaust with the tungsten divertor. The optimization of X-point, plasma shape, the outer gap and local gas puffing near the low hybrid wave (LHW) antenna were integrated with global parameters of BT and line-averaged electron density for higher current drive efficiency of LHW and on-axis deposition of electron cyclotron heating in the long-pulse operation. More recently, a high βP RF-only discharge (βP ~ 1.9 and βN ~ 1.5, /nGW ~ 0.80, f bs ~ 45% at q95 ~ 6.8) was successfully maintained over 24 s with improved hardware capabilities, demonstrating performance levels needed for the China Fusion Engineering Test Reactor steady-state operation. A higher energy confinement is observed at higher βP and with favorable toroidal field direction. Towards the next goal (⩾400 s long-pulse H-mode operations with ~50% bootstrap current fraction) on EAST, an integrated control of the current density profile, pressure profile and radiated divertor will be addressed in the near future.

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