A facile conversion of 6-(2-arylidenehydrazineyl) purines to [1,2,4] triazolo [3,4-i] purines is presented using PhI(OAc) 2 as oxidant in only 10 min under room temperature. This approach is metal-free, wide functional group tolerant, and provides an efficient and convenient method to synthesize purine-fused tricyclics.
A metal‐, light‐free radical alkylation reaction of purines and nucleosides has been achieved with readily available alcohols (1°, 2°, 3°) as the alkyl radical sources enabled by oxalates, which does not need any catalysts, N2 protection, and protecting groups. Although there are three potential active C(sp2)H bonds and four interferential nitrogen atoms in the purine motif, the reaction still shows excellent regioselectivity at C6H position and does not face multialkylation problem. Besides, this approach shows broad functional groups tolerance and is scalable to the gram level, which can be applied to late‐stage CH alkylation of purine to synthesize 6‐cyclopentyl nebularine with anti‐CEM activity, thus demonstrating its utility.
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