Hydroxylamine derivatives are commonly used as both nitrogen and oxygen sources in the aminohydroxylation of alkenes, which is a powerful and practical method for the rapid assembly of synthetically useful 1,2-aminoalcohols. In this work, we disclose an unprecedented asymmetric formal aminohydroxylation of two diazo compounds with O-benzyl hydroxylamines, which involves a N–O bond activation, fragment modification, and reassembly cascade process. This cascade reaction forms multiple bonds in one-pot, including CN, C–O, and C–C bonds, providing a potent complement for the aminohydroxylation using alkenes to that using two different diazo compounds, and leading to chiral α-alkoxy-β-amino-carboxylate derivatives with two adjacent tertiary chiral centers in generally good yields and high to excellent enantioselectivity.

A Rh2(OAc)4 catalyzed intermolecular Aldol-type interception of phenolic oxonium ylides with isatins has been developed that provides an effective access to the 2,2-disubstituted dihydrobenzofuran derivatives containing 3-hydroxyoxindole in high yields...

Herein, we design and develop a one-pot cascade strategy for the assembly of multi-substituted conjugate oxindole derivatives. This approach represents a new reaction mode for carbene gem-difunctionalization by delayed acyl transfer instead of delayed proton transfer.

A copper-catalyzed three-component reaction of dithioacetals with diazo-ketones and ketimines has been reported. This reaction proceeds via trapping of the highly active sulfur ylide species, which generated from thioacetal and...