An efficient and eco-friendly method for the synthesis of pyrrolo[1,2-a]quinoxalines is presented. Compared to previous methods, this protocol is transition-metal-free and only [a

A series of 1,4-thiazepin-5(4H)-one derivatives were synthesized via a transition metal-free one-pot Smiles rearrangement process at room temperature. Regioselective seven-membered heterocycles were constructed in good to excellent yields. To gain an in-depth understanding of the S-N type Smiles rearrangement mechanism, a theoretical study was also performed by quantum chemistry calculations.

A direct C–H bond carbamoylation of quinoxalin‐2(1H)‐ones with hydrazinecarboxamides has been developed. This reaction provides a series of 3‐carbamoylquinoxalin‐2(1H)‐one derivatives in moderate to good yields under mild conditions with a broad range of substrates and functional group tolerance. The present methodology affords a convenient and practical access to pharmaceutically active 3‐carbamoylquinoxalin‐2(1H)‐one derivatives.

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