The emergence of multimedia has created a new teaching vitality for the development of English teaching, and at the same time stimulated students’ interest in learning and made the whole classroom more diverse and interesting. It is a new way for people to use modern technology to assist teaching. This article proposes CD-ROM self-learning and face-to-face teaching to guide and inspire multimedia teaching. Studying the type, construction and function of interactive English teaching mode in multimedia environment is of great significance to the reform of English teaching in colleges and universities. Therefore, it is necessary for teachers engaged in open English teaching to explore suitable combination of human-machine and English-based teaching modes based on network multimedia independent learning and face-to-face teaching. The novelty of this article is based on the experience of full-time colleges and universities, and considering the particularity of college English teaching, a teaching model based on open English multimedia CD-ROM and face-to-face teaching was constructed. Based on language input theory, this research fully considers the central role of students, uses a set of multimedia CD-ROM autonomous learning system while teaching face-to-face, integrates tests and questionnaires, carries out a year-long teaching experiment. The experimental results show that it is an effective open English teaching model.