Developing bio-multifunctional patches with natural extracellular matrixlike structures, excellent high adhesion in the wet state, self-healing ability, antibacterial activity, and favorable cell responses for accelerating tissue healing is highly desirable in clinical applications. Herein, bio-multifunctional composite hydrogels are developed by coupling carboxymethyl chitosan and 4-arm poly (ethylene glycol) aldehyde for full-thickness abdominal wall defect repair. The prepared hydrogels exhibit excellent self-healing and mechanical properties, high adhesion in the wet state, and significant antibacterial ability. In vitro cellular experiments show that the hydrogels combined with recombinant bovine basic fibroblast growth factor remarkably promote cell proliferation and then accelerate full-thickness abdominal wall defect repair in a rat model. The histomorphological evaluation shows that compared to the commercial polypropylene mesh used clinically, the designed hydrogel patches facilitate an increase in the thickness and integrity of the abdominal wall tissue by upregulating the production of Ki67, enhancing the formation of collagen, inducing neovascularization, and inhibiting inflammation by reducing the expression of IL-6, TNF-α, and IL-1β. The results demonstrate that this novel bio-multifunctional hydrogel patch holds great potential for the treatment of full-thickness abdominal wall defects.

Groin hernioplasty is the most performed intervention in the adults worldwide, the minimally invasive inguinal hernia repair techniques widely used by surgeons today are transabdominal preperitoneal patch plasty (TAPP) and total extraperitoneal patch plasty (TEP). We report a 62-year-old man with bowel obstruction caused by the use of self-anchoring barbed suture to close the peritoneum 3 days after TAPP. Surgeons using the barbed suture should be alert to this possibility when encountering this complication of intestinal obstruction, so as to avoid more serious consequences.

Objective: To investigate the effect and value of perioperative nursing intervention on postoperative recurrent grade II-I left frontal astrocytoma. Method: Nursing care procedures: left frontal lobe of the patient was occupied by a large space. Clinical teaching of nursing was strengthened. Preoperative, intraoperative and postoperative care and ward patrol were enhanced. Close attention was paid on consciousness, pupil, vital signs, body temperature, lungs condition, cranial and nerve function of the patient. Extra care was taken in keeping the incision clean and dry. Blood diffusion condition in wound was observed. Active cooperation with doctor was taken to prevent occurrence of pulmonary infection, urinary tract infection, pressure ulcer and other complication. Results: After operation, the patient had stable condition, clear mind and consciousness. There was no occurrence of epilepsy but intracranial hemorrhage. Pneumatosis was relieved. There was no infection and other complication. Conclusion: Application of comprehensive nursing intervention could effectively improve quality of life of patient and reduce incidence of postoperative complication in patients with brain tumor.