The dehydrogenation of heavy paraffins is an important process for the production of linear alkyl benzene. In this paper, a one-dimensional pseudohomogeneous model for a adiabatic radial reactor is used to simulate an industrial dehydrogenation reactor. Combined with 17-lumped intrinsic reaction kinetics over the NDC-10 (Pt/γ-Al 2 O 3 type) dehydrogenation catalyst, the industrial dehydrogenation double-ring radial reactor model was deduced, and the catalyst deactivation model was established as well. The kinetic parameters were optimized by a Sequential Quadratic Programming (SQP) method, and the catalyst deactivation parameters were estimated by fitting the trend of catalyst activity. The results showed that there is good agreement between the calculated value and actual value. The effect of different operating conditions on the reaction system was investigated. According to the established catalyst deactivation model, operating conditions were reasonably adjusted to increase the yield of the desired product or extend the usage time of the catalyst, which can provide guidance for industrial production.