Size regulation of polydopamine nanoparticles (PDA NPs) is vital to melanin‐inspired materials. The general strategy usually focuses on tuning of the reaction parameters which could affect the dopamine (DA) monomer polymerization process, such as pH, temperature, monomer concentration, etc. The reaction between boronic acids and catechols to form boronic esters has been widely applied in many fields, but little attention has been paid in the size regulation of PDA NPs. Here, it is speculated that the fine size regulation of PDA NPs can be directly achieved by using boronic acids and Lewis base molecules. It is found that these issues could indeed significantly affect the stability of the boronic esters formed by boronic acids and DA, which may further inhibit the monomer polymerization kinetics and tune the particle size of the resulting PDA NPs. It is also found that the several intrinsic properties of PDA NPs such as the free radical scavenging ability, UV spectral absorption, photothermal behavior, and structural color all change with the particle size. It is believed that this work can provide new opportunities for fabricating melanin‐inspired PDA NPs with well controlled size and properties.

A convenient method was developed to prepare the diastereomer of dolutegravir tricyclic intermediate in the catalysis of EDCI/DMAP in up to 87% yield. Different solvents, temperature, and times were optimized. The synthesized diastereomer 6′ could be used as a standard for the industrial manufacture requirement of dolutegravir active pharmaceutical ingredient.

In this paper, a series of novel derivatives of camptothecin substituted norcantharimide was designed by mimic strategy. These compounds were synthesized in moderate yields by directly coupling CPT with N-amino acid norcantharimides. Their cytotoxicity to four human tumor cell lines (HepG2, BGC-803, SW480 and PANC-1) and normal human cell lines L-O2 and HIEC was evaluated. The synthesized CPT substituted norcantharimide analogs (3g and 3f) showed better anti-hepatocarcinoma activity than CPT. Compounds 3d, 3e, 3g, 3h and 3i also showed strong inhibition activity against BGC803.

BSA-seq has been widely used for identifying the genomic regions affecting a certain trait. In this study, we developed a modi ed BSA/BSR-seq method, which we named Phenotypic Recombination BSA/BSR (PR-BSA/BSR), to simultaneously identify candidate genomic regions associated with two traits in a segregating population. Lateral branch angle (LBA) and ower-branch pattern (FBP) are two important traits associated with the peanut plant architecture because they affect the planting density and light use e ciency. We generated an F 6 population (with two segregating traits) derived from a cross between the inbred lines Pingdu9616 (erect and sequential; ES-type) and Florunner (spreading and alternating; SAtype). The selection of bulks with extreme phenotypes was a key step in this study. Speci cally, 30 individuals with recombinant phenotypes [i.e., spreading and sequential (SS-type) and erect and alternating (EA-type)] were selected to generate two bulks. The transcriptomes of individuals were sequenced and then the loci related to LBA and FBP were simultaneously detected via a ΔSNP-index strategy, which involved the direction of positive and negative peaks in the ∆SNP-index plot. The LBArelated locus was mapped to a 6.82 Mb region (101,743,223-108,564,267 bp) on chromosome B05, whereas the FBP-related locus was mapped to a 2.16 Mb region (117,682,846,824 bp) on chromosome B02. Furthermore, the marker-based classical QTL mapping method was used to analyze the PF-F 6 population, which con rmed our PR-BSA/BSR results. Therefore, the PR-BSA/BSR method produces accurate and reliable data.

A new series of norcantharidin salt derivatives was designed and synthesized in good yield. The compounds structures were characterized by 1H‐NMR, 13C‐NMR, and IR spectra. These norcantharidin salts 5 exhibit good antitumor activity against both liver cancer and colon cancer cell lines in vitro, which seems to direct a right trend for the modification on cantharidin structure.