Leptosparones A–F (1–6), six new dimeric acylphloroglucinol derivatives with unprecedented skeletons, were isolated from Leptospermum scoparium. Compounds 1–3 and 5–6 are phenylpropanoyl‐phloroglucinol dimers, while 4 is a phenylpropanoylphloroglucinol‐isovalerylphloroglucinol hybrid. Structurally, these compounds represent the first examples of dimeric phloroglucinols with unprecedented C(7′)−C(8) linkage between the phloroglucinol core and the acyl side chain. Their structures were elucidated by comprehensive analyses of spectroscopic data, single crystal X‐ray diffraction and chemical calculations. In addition, all compounds showed inhibitory effects against α‐glucosidase with IC50 values ranging from 39.5 to 186.8 μM.

Five monoterpenoid indole alkaloids (MIAs) with unusual skeletons, gelserancines A-E (1-5), along with their postulated biosynthetic intermediates (6-10) were isolated from the roots of Gelsemium elegans. Compound 1 featured a...

Front Cover. Leptospermum scoparium (Myrtaceae) is well known as the source plant of manuka honey. In a search for bioactive phloroglucinol derivatives from family Myrtaceae, six new dimeric acylphloroglucinols (leptosparones A–F) were isolated from the leaves of L. scoparium. These compounds represent the first examples of dimeric phloroglucinols with C(7')−C(8) linkage between the phloroglucinol core and the acyl side chain. Furthermore, these compounds exhibited α‐glucosidase inhibitory activities, as reported by Kai Xia, Ji‐Hong Gu et al. in their full paper at 10.1002/cbdv.202100252.