Objectives:Childhood obesity/underweight status and caries are both important public health problems. This study aims to investigate the caries status and its association with body weight in 8-year-old children in Qingdao, China.Materials and Methods:We initiated a cross-sectional investigation on 744 children aged 8 years during the Oral Health Survey in 2012. Dental caries assessments were carried out and weight status was recorded accordingly. The resulting caries status including caries prevalence, dmft (deciduous dentition), and (dmft + DMFT) (mixed dentition), as well as BMI indices were analyzed for comparison and correlation.Results:The prevalence of dental caries among the 744 children aged 8 years participating in this survey was 86.3%. The caries status represented by dmft (deciduous dentition) and (dmft + DMFT) (mixed dentition) values was 4.31 and 4.85, respectively, and the restoration rate was extremely low, which was no more than 3.0%. Significant difference was found in dmft/(dmft + DMFT) values between different BMI groups, and underweight individuals were found to have the highest dmft/(dmft + DMFT) value. An inverse relationship between body BMI and dmft/(dmft + DMFT) index was identified based on Pearson's correlation.Conclusions:A severe state of caries disease was revealed in 8-year-old children in the Chinese city of Qingdao, for whom urgent dental intervention and treatment were needed. Furthermore, underweight individuals were found with the most severe caries experience, indicating caries may affect the development and growth of the afflicted children. Thus, more emphasis should be placed on improving their dental health, with caries prevention being given the priority.

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To retrospectively analyze the safety and efficacy of 350–560 μm gelatin sponge particles combined with single-chemotherapy drug transcatheter arterial chemoembolization (Gs-TACE) for the treatment of elderly hepatocellular carcinoma without surgical resection.Thirty elderly hepatocellular carcinoma patients without surgical resection, who received Gs-TACE in our hospital, were selected. Slowly injected gelatin sponge particles (350–560 μm)+ 10 mg lobaplatin injection into the regional embolization tumor target vessel. The Response Evaluation Criteria for Solid Tumors could be used to evaluate the tumor response after intervention surgery.Eighty-nine times of intervention TACE were conducted on the 30 patients. The average size of tumor was 8.3 cm. The median survival time was 28 months, and the 1 and 2-year survival rates were 89% and 58%, respectively. The Response Evaluation Criteria for Solid Tumors was used to evaluate the tumor response, and found that the complete response, partial response, and OR were 30%, 56.67%, and 86.67%, respectively, at 1 month after intervention surgery. The patients were divided into groups: 60 to 65 years age group (A), >65 to 75 years age group (B), and >75 years age group (C); the median survival times were 16, 32, and 33 months, respectively, and there was statistical difference between A group, B group, and C group. The analysis of prognosis factors showed that there was statistical significance in age, Barcelona Clinic Liver Cancer stage, portal vein invasion, and alpha fetal protein (AFP), and age was the protective factor.Gelatin sponge particles (350–560 μm), combined with transcatheter arterial chemoembolization, provide an alternative method for the treatment of elderly hepatocellular carcinoma without surgical resection.

Background:The association between the tumor necrosis factor-alpha gene (TNF-a) -238G/A polymorphism and the breast cancer has been analyzed in several studies, but the results have been inconclusive. We then performed a meta-analysis to get a precise estimation of the association.Methods:Eight case–control studies with a total of 37,257 cases and 39,564 controls were identified by searching the ISI Web of Knowledge database and the PubMed database up to August 2014.Results:Overall, no association was found between TNF-alpha-238G/A polymorphism and breast cancer in any of genetic model (additive model OR = 1.06, 95%CI: 0.94–1.21, Pheterogeneity = .02; homozygous model OR = 1.04, 95%CI: 0.83–1.30, Pheterogeneity = .98; dominant model OR = 1.06, 95%CI: 0.92–1.21, Pheterogeneity = .01; recessive model OR = 1.04, 95%CI: 0.83–1.30, Pheterogeneity = .98). Furthermore, no significant association was identified when stratified by ethnicity (Caucasian, Asian).Conclusion:This meta-analysis indicated that the TNF-alpha-238G/A polymorphism is not associated with breast cancer risk in the overall population.

This study aims to investigate dietary exposure to acrylamide (AA) and also make an assessment of its effect on the neurobehavioral performance and oxidative stress in the serum of university students in Ningxia. The place primarily consists of arid, dry desert, and wheat‐based foods are the staple food there. A total of 803 university students in Ningxia participated in this cross‐sectional study. Diet intake of AA was estimated with FFQ. The AA risk was calculated as margin of exposure (MOE) values. NCTB questionnaires were used to assess neurobehavioral performance. The serum oxidative stress levels of the university students were measured as GSH, MDA, and SOD. The mean for AA exposure of university students was 0.515 μg kg −1 bw day −1 . The highest contributor was traditional Chinese grain products, representing 34.71% of the total daily AA intake. Followed were deep‐fried potato products, traditional Western grain products, soft drinks, and nuts, which accounted for 23.87%, 16.59%, 11.15%, and 11%, respectively. The median AA exposure were 480 (BMDL 10 = 0.18 mg kg −1 bw day −1 ) and 827 (BMDL 10 = 0.31 mg kg −1 bw day −1 ), respectively. The results indicated that diet AA may have an effect on the emotional status and neurobehavior among this population. We observed no significant differences in oxidative stress under the three levels of AA exposure ( p > .05). It suggests a health concern for university students in Northwest China that should get society's attention.