An aluminium(III) chloride-catalyzed three-component reactiono fa romatic aldehydes, nitroalkanes, and sodium azide hasb een developed; this reaction sequence can be applied to ab road substrate scope anda ffords the corresponding 4-aryl-NH-1,2,3-triazoles in good to excellent yields. Them ilder reactionc onditions and easier operation make this AlCl 3 -catalyzed protocolm ore advantageous for the synthesis of 4-aryl-NH-1,2,3-triazoles.

An efficient copper-catalyzed C-N bond formation by N-H/C-H cross-dehydrogenative coupling (CDC) between NH-1,2,3-triazoles and N,N-dialkylamides has been developed. The method provided N-amidoalkylated 1,2,3-triazoles with moderate to high yields, and the reactions showed high N-selectivities when 4,5-disubstituted NH-1,2,3-triazoles served as the substrates.

A new efficient Mn(iii)-mediated coupling reaction of sodium sulfinates with nitro-olefins is described.

No abstract