Hydrogel has a similar structure and function as the extracellular matrix and is expected to be used for wound adhesion and hemostasis. However, traditional hydrogels have poor adhesion and no self-healing function, and mechanical properties are also limited. Inspired by mussel and adherent DNA, the triple-crosslinking conductive self-healing hydrogel (CaSA-GAD hydrogel) containing calcium ions (Ca 2+ ), sodium alginate, acrylated guanine, acrylamide, and acrylated dopamine was constructed through UV irradiation, including a G−C pairing hydrogen bond dynamic network, a chemical cross-linking network, and an ionic crosslinking dynamic network. The hydrogel exhibits strong adhesion to various surfaces and peeling properties in the bonding of tissues. With high toughness, the hydrogel can be stretched and compressed without damage. The self-healing property further ensures the mechanical properties of the hydrogel. By loading calcium ions to reduce the impedance of the hydrogel greatly, the wound can be monitored at the same time when the wound is bonded. Both fresh and freeze-dried hydrogel can be used to bond the wound on pork stomach and the scope of application of as wound adhesive increases. In addition, the hydrogel can be used as a sensitive sensor to monitor human movement.

Background: The preparation of Dendrobium officinale flower soft candy was optimized based on orthogonal tests, texture profile analysis (TPA), and sensory properties. A concentrated flower extract served as the raw material, with gelatin and agar powder serving as the gelling agent. The optimal amount of each component in the candy was studied. Nutrient content and antioxidant activity were also determined for the soft candy. Results:The amount of each component in the candy affected the hardness, chewability, toughness, and elasticity. With a total sugar content of 500 g, the soft candies prepared with 30% concentrated flower extract, 15% gelling agent, 25% sweetener, and 0.14% acidulant showed appropriate hardness, springiness, resilience, and chewiness, and this particular preparation achieved the highest sensory score of 90.01. The soft candies contained 2.24% flavonoids and showed free radical scavenging activities against 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) (69.7%) and 2,2-azido-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) (61.2%). The candies also contained protein, carbohydrates, sodium, and other nutrients, suggesting that they are suitable for consumption by the general population. Conclusion:The optimal formulation of the soft candies was determined by orthogonal experiments and exhibited appropriate flavor, texture, and moderate nutritional value.

Based on the excellent photothermal conversion performance of graphene oxide (GO) and the shrinkage of thermoresponsive copolymer chain segments, a GO–polymer hybrid hydrogel carrier system was designed to load stem cell exosomes that have repair and nutritional functions on nerve cells and play a synergistic role in the proliferation and migration of Schwann cells (SCs). The surface modification of hydroxypropyl chitosan on GO was carried out based on the EDC reaction, and GO–hydroxypropyl chitosan (GC) with well hydrophilicity and dispersion was obtained. The thermoresponsive copolymer poly­(2-hydroxyethyl methacrylate-co-2-(2-methoxyethoxy) ethylmethacrylate-co-oligo­(ethylene glycol) monomethyl ether methacrylate) (P­(HEMA-co-OEGMA-co-MEO2MA), PHOM) was prepared by atom transfer radical polymerization. After aldehyde modification, PHOM–CHO was cross-linked with GC through a dynamic Schiff base bond to form a thermoresponsive hydrogel. Due to the near-infrared (NIR) photothermal conversion of GO and the thermoresponsive contraction of the hydrogel network, the hydrogel can achieve controlled release of the loaded exosomes. Cell experiments showed that the GO–thermoresponsive polymer hybrid hydrogel had good biocompatibility. Further tests on the promoting effect of the exosome-loaded hydrogel on Schwann cells (SCs) showed that the exosomes could be released in a controlled way through NIR irradiation, and the synergistic effect of exosomes and the GO hybrid hydrogel promoted the proliferation and migration of SCs.

In order to overcome the limitation of traditional therapies for cancer and improve the accuracy of treatment, more advantageous cancer treatment methods need to be explored and studied. As a result, photothermal photodynamic therapy of breast cancer using bovine serum albumin (BSA) modifies molybdenum disulfide nanoflakes. Then the well‐dispersed BSA‐MoS2 NFs are loaded in the injectable and self‐healing polysaccharide hydrogel which is prepared by the reaction of oxidized sodium alginate (OSA) and hydroxypropyl chitosan (HPCS) through the formation of Schiff base bonds. The injection and self‐healing properties of the nanocomposite hydrogel are investigated. In vitro photothermal and photodynamic investigations demonstrate that BSA‐MoS2 NFs possess obvious photothermal conversion and production of reactive oxygen species (ROS) under the irradiation of near infrared (NIR) laser (808 nm). In vivo anticancer investigation indicates that the nanocomposite hydrogel can be directly injected and remain in the tumor sites and achieve the synergistic photothermal‐photodynamic therapy of cancer.