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Long non‐coding RNAs (lncRNAs) have been highlighted as prominent genetic modulators involved in multiple important biological processes of cancer cells, especially in esophageal cancer (EC). We tried to elucidate the potential role of LINC00337 in the progression of EC. Based on TCGA database analysis and Reverse transcription quantitative polymerase chain reaction determination, high expression of LINC00337 and FSCN1 was detected, while miR‐145 exhibited a low expression in EC. LINC00337 was identified to bind to miR‐145 to impair the miR‐145‐dependent FSCN1 inhibition. The underlying regulatory mechanisms were evaluated by transfection with LINC00337 overexpression plasmid, siRNA against LINC00337, miR‐145 mimic, or anta‐miR‐145. Downregulation of LINC00337 results in increased Bax level, decreased FSCN1, Bcl‐2, VEGF, and p53 levels, in addition to diminished cell proliferation, migration, invasion and tumor growth, with accelerated cell apoptosis by upregulating miR‐145. Taken together, the findings obtained provided evidence suggesting that LINC00337 acts as a tumor promoter in EC, providing insight and advancements for EC treatment.

Objective Hormone replacement therapy (HRT) is the most effective treatment for hot flushes, which is the most common symptom of the climacteric. This study aims to explored whether estrogen can relieve the hot flushes of menopause by regulating the secretion of exosomal miRNA. Methods For perimenopausal women with obvious symptoms of hot flashes, miRNAs in plasma exosomes were extracted and sequenced before and after HRT, miRNA expression profiles were analyzed, and target gene prediction and functional analysis of miRNAs with large differences in expression were performed. Results The symptoms of hot flashes improved significantly after HRT. 22 significantly differential expressed exosomal miRNAs were screened after HRT, of which 14 were down-regulated and 3 up-regulated, and 5 were newly annotated differential miRNAs. Target gene prediction and functional analysis of miRNA also suggest that it may have a certain relationship with vasomotor symptoms. Conclusion The types and quantity of miRNA in plasma after HRT improves the symptoms of hot flashes are different from those before treatment. More specific ways of action still need to be experimentally verified.