Power oscillation and current quality are the important performance targets for the grid-connected inverter under unbalanced grid faults. Firstly, the inherent reason for the current harmonic and power oscillation of the inverter is discussed with a quantitative analysis. Secondly, a new control strategy is proposed to achieve the coordinate control of power and current quality without the need for a phase-locked loop (PLL) or voltage/current positive/negative sequence extraction calculation. Finally, the experimental tests are conducted under unbalanced grid faults, and the results verify the effectiveness of the propose method.
Eliminating the leakage current is one of the most important issues for transformerless three phase photovoltaic (PV) systems. In this paper, the leakage current elimination of a three-phase four-leg PV inverter is investigated. With the common mode loop model established, the generation mechanism of the leakage current is clearly identified. Different typical carrier-based modulation methods and their corresponding common mode voltages are discussed. A new modulation strategy with Boolean logic function is proposed to achieve the constant common mode voltage for the leakage current reduction. Finally the different modulation methods are implemented and tested on the TMS320F28335 DSP +XC3S400 FPGA digital control platform. The experimental results verify the effectiveness of the proposed solution.Index Terms-Transformerless photovoltaic system, three-phase four-leg inverter, pulse width modulation, leakage current
The mechanisms underlying trigeminal pain conditions are incompletely understood. In vitro animal studies have elucidated various targets for pharmacological intervention; however, a lack of clinical models that allow evaluation of viable innervated human tissue has impeded successful translation of many preclinical findings into clinical therapeutics. Therefore, we developed and characterized an in vitro method that evaluates the responsiveness of isolated human nociceptors by measuring basal and stimulated release of neuropeptides from collected dental pulp biopsies.
Informed consent was obtained from patients presenting for extraction of normal wisdom teeth. Patients were anesthetized using nerve block injection, teeth were extracted and bisected, and pulp was removed and superfused in vitro. Basal and capsaicin-evoked peripheral release of immunoreactive calcitonin gene-related peptide (iCGRP) was analyzed by enzyme immunoassay. The presence of nociceptive markers within neurons of the dental pulp was characterized using confocal microscopy.
Capsaicin increased the release of iCGRP from dental pulp biopsies in a concentration-dependent manner. Stimulated release was dependent on extracellular calcium, reversed by a TRPV1 receptor antagonist, and desensitized acutely (tachyphylaxis) and pharmacologically by pretreatment with capsaicin. Superfusion with phorbol 12-myristate 13-acetate (PMA) increased basal and stimulated release, whereas PGE2 augmented only basal release. Compared with vehicle treatment, pretreatment with PGE2 induced competence for DAMGO to inhibit capsaicin-stimulated iCGRP release, similar to observations in animal models where inflammatory mediators induce competence for opioid inhibition.
These results indicate the release of iCGRP from human dental pulp provides a novel tool to determine the effects of pharmacological compounds on human nociceptor sensitivity.
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