Background:The primary function of the abundant and highly conserved protein TCTP is not clear. Results: TCTP binds to a conserved central acidic region of eukaryotic elongation factor 1B␣//␦. Conclusion: The binding of TCTP to eukaryotic elongation factor 1B is evolutionarily conserved. Significance: The interaction with eEF1B represents a primary function of TCTP.
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