Objectives To explore the risk factors for systemic lupus erythematosus (SLE) flare and their impact on prognosis. Methods The clinical characteristics, laboratory results, and treatment plans of 121 patients with SLE flare were retrospectively analyzed. Ninety-eight SLE outpatients with sustained remission during the same period were selected as controls. Logistic multivariate regression analysis was employed to screen for risk factors for SLE flare. Results Infection, thrombocytopenia, arthritis, anti-nucleosome antibodies positive, anti-β2-glycoprotein I (IgG) antibodies positive, and patient’s self-discontinuation of medicine maintenance therapy might be risk factors for SLE flare. Patients who discontinued medicine maintenance therapy by themselves had a significantly higher rate of severe SLE flare than patients with regular medicine maintenance therapy (P = 0.033). The incidence of anemia associated with SLE (P = 0.001), serositis (P = 0.005), and pulmonary hypertension (P = 0.003) in patients who discontinued medicine maintenance therapy were significantly higher than patients with regular medicine maintenance therapy. SLE patients with regular medicine maintenance therapy for less than 3 years had a higher risk of pulmonary hypertension than those with regular medicine maintenance therapy longer than 3 years (P = 0.034). Conclusions The accompanying thrombocytopenia, arthritis, anti-nucleosome antibodies positive and anti-β2-glycoprotein I (IgG) antibodies positive at the onset of SLE may affect the prognosis of SLE. Patient’s self-discontinuation of medicine maintenance therapy is the main cause of SLE flare, which may induce severe flare in SLE patients and lead to a significantly higher incidence of pulmonary hypertension.

The nuclear magnetic resonance image (MRI) improved the positive rate of diagnosis in patients with nasopharyngeal carcinoma (NPC) and paranasal sinuses infringed, recently. But the reports about MRI features for involvement of paranasal sinuses in NPCs were less. In the study, the MRI features of 56 patients with NPC and paranasal sinuses infringed were evaluated between December 2003 and August 2004. And that would be propitious to therapy. Materials and methods Clinical dataFifty-six NPC patients with paranasal sinuses infringed were reviewed. There were 42 males and 14 females. The age ranged from 14 to 79 years, and the mean age was 49.5 years. All patients were diagnosed by pathology, and made MRI check before therapy. MRI dataThe MRI data of 56 NPC patients saved in the PACStapionPM 3.0 image scan system, could be scanned at any moment. Study methodsAll patients made 1.5 T MRI check on their backs. The tier thickness of MRI scan was 6 mm, and the space between tiers was 1 mm. All cases were gathered the enhanced MRI scan in sagittal section, coronal section and horizontal section, and gathered the T1W1, T2W1 MRI scan at the same time. By means of the tumour in involvement of sinus and sinuses wall, mucous membrane in sinuses, the encroaching routes were conjectured. We compared the positive rates of diagnosis in each scan lists. All the MRI scan results were read by one radiation doctor and two radiotherapy doctors. MRI diagnosis for involvement of paranasal sinusesTumour destroyed sinuses wall, or intruded into sinuses and lock-in sinuses in one MRI scan list. The whole tumour had the same signal. It showed equal signal or lower signal in T1W1 MRI scan. It showed equal signal or higher signal in T2W1 MRI scan. And it showed obvious enhancement in the enhanced MRI scan. Statistical analysisThe positive rates of paranasal sinuses infringed in each MRI scan list were compared by χ 2 test. While P < 0.05, it was positive in statistical analysis.Abstract Objective: The aim of the study was to study the nuclear magnetic resonance image (MRI) feature for involvement of paranasal sinuses in patients with nasopharyngeal carcinoma (NPC). Methods: The MRI of 56 patients with NPC and paranasal sinuses infringed were evaluated between December 2003 and August 2004. Results: Among them, 56 (100%) showed breakage in the wall of paranasal sinuses, 29 (51.8%) had thick mucous membrane in sinuses, 36 (64.3%) showed tumour invasion sinuses, 55 (98.2%) connected with primary carcinoma with the lesion, and 14 (25%) stored up fluid in sinuses. On MRI scan technique, the positive ratios of diagnoses were 66.1%, 76.8%, and 98.2% respectively (P < 0.000) in the horizontal section, coronal section and sagittal section. And nearly 60% was in the T1W1 and T2W1, but 100% in strengthen scan. Conclusion: The findings of sinuses wall breakage, thick mucous membrane in sinuses, tumour invasion cavity connective mass, and same enhancement signal in MR image may indicate the paranasal sinuses involved by primary tumour. The sagittal sectio...

Introduction In recent axSpAx patients with remission lasting at least 3 months and later followed-up monthly for a median of 8 months, we compared the predictive value of baseline MRI of sacroiliac joints and constructed a nomogram model for predicting flare. Methods This study included 251 patients with axial spondyloarthritis, according to the ASAS axSpA classification criteria, who achieved Low Disease Activity (ASDAS) and underwent MRI examination. A total of 144 patients from the First Affiliated Hospital of Xiamen University were used as the nomogram training set; 107 from the First Affiliated Hospital of Fujian Medical University were for external validation. Results The median time of relapse was 8.705 months (95% CI 8.215–9.195) and 7.781 months (95% CI 7.075–8.486) for MRI-positive patients and 9.8 months (95% CI 9.273–10.474) for MRI negative patients, respectively. Both active sacroiliitis on MRI (HR 1.792, 95% CI 1.230–2.611) and anti-TNF-α treatments (HR 0.507, 95% CI 0.349–0.736) were significantly associated with disease flares. Gender, disease duration, HLA-B27, MRI, and anti-TNF-α treatment were selected as predictors of the nomogram. The areas under the ROC curve (AUROCs) of the 1-year remission probability in the training and validation groups were 0.71 and 0.729, respectively. Nomogram prediction models present better AUROCs, C-indices, and decision curve analysis cure than the clinical experience model. Conclusions Active sacroiliitis in MRI requires weighting in order to estimate remission and disease flares, when axSpA patients achieve low disease activity. The simple nomogram might be able to discriminate and calibrate in clinical practice. Trial registration ClinicalTrials, NCT03425812, Registered 8 February 2018, https://clinicaltrials.gov Supplementary Information The online version contains supplementary material available at 10.1007/s40744-021-00279-y.