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A series of pH-and temperature-responsive poly(N-isopropylacrylamide-co-acrylic acid derivative) (P(NIPAM-co-AAD)) copolymers and hydrogels were prepared. The lower critical solution temperatures (LCSTs) of the copolymers exhibited a dependence on both pH and the hydrophobicity of the AAD unit. The influence of pH and temperature on the equilibrium swelling ratio of the hydrogels was investigated. The hydrogels displayed a unique thermo-induced swelling-deswelling transition that can be self-regulated to occur at above or below the physiological temperature in response to the environmental pH. Scanning electron microscopic (SEM) analysis revealed porous sponge-like microstructures of the hydrogels. Insulin was loaded into the hydrogels as a model protein, and the in vitro release profiles indicated that the loaded protein could be protected within the hydrogels in an acidic environment and selectively released in neutral medium. MTT assay proved that both the copolymers and hydrogels are nontoxic. After oral administration of the insulin-loaded hydrogels to streptozotocin-induced diabetic rats at 60 IU per kg, the fasting plasma glucose level was reduced continuously to 72.1% within 6 h. The bioavailability of hydrogel-encapsulated insulin via the oral administration to healthy rabbits reached 5.24%, which is much higher than that of pure insulin solution given orally. These results showed that the smart copolymers and hydrogels may hold great promise for pH-triggered drug delivery systems.

Biodegradable and pH-responsive carboxymethyl cellulose/poly(acrylic acid) hybrid hydrogels are synthesized. The hydrogels deswell in acidic artificial gastric fluid (AGF) but rapidly swell in neutral artificial intestinal fluid (AIF), rendering selective enzymatic degradation of the gels as well as accelerated drug release from insulin-loaded hydrogels in AIF. Oral administration of insulin-loaded hydrogels to streptozotocin-induced diabetic rats leads to a continuous decline in the fasting blood glucose level within 6 h post-administration, and the relative pharmacological availability increases more than 10 times compared to oral administration of free insulin solution. The relative bioavailability of hydrogel-encapsulated insulin after oral administration to healthy rabbits is 6.6%.

The Three-North Shelter Forest Programme (TNSFP) covers 551 Chinese counties and an area of 4,069,000 km 2 mostly in arid and semi-arid regions. In this paper, we discuss the temporal and spatial changes in value of the normalized-difference vegetation index (NDVI) in this region, and the relationships between NDVI and climatic factors (temperature and precipitation) based on NOAA Advanced Very High Resolution Radiometer Global Inventory Modeling and Mapping Studies NDVI data with 8-km resolution from 1982 to 2006. During the past 25 years, the vegetation cover has generally increased in eastern regions of China and the oasis in the north piedmont of Tianshan Mountains, but has decreased northwest of Xinjiang and in the Hulunbeier Plateau. The multi-year monthly average NDVI distribution map showed that NDVI increased from April to August, but in the western and northern plateau areas, the lower temperatures and high altitude created a shorter growing season (1 or 2 months). The vegetation of the study area has generally increased in the regions covered by the TNSFP. Linear regression analysis of the vegetation cover showed an increasing trend over large areas. The largest annual growth rate per pixel (the slope of the regression) was 0.009; the largest negative annual change was -0.004. The correlation between NDVI and precipitation was higher than that between NDVI and temperature, suggesting that precipitation is the most important factor that affects NDVI changes in the study area, especially for temperate desert vegetation in northwestern China.

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