Background Emerging studies have shown the effectiveness of mobile health (mHealth) interventions in reducing depressive symptoms among people living with HIV. Most of these studies included only short-term follow-up, with limited data on long-term effects. Objective The purpose of this study is to assess the long-term effects of a randomized controlled trial called Run4Love on depressive symptoms among people living with HIV at 1-year and 3-year follow-ups. Methods A total of 300 people living with HIV with depressive symptoms were recruited and randomized to an intervention or a control group in Guangzhou, China, from September 2017 to January 2018. The intervention group received a 3-month Run4Love program, including adapted evidence-based cognitive behavioral stress management courses and exercise promotion via WeChat (Tencent), a popular social media app. The control group received usual care and a brochure on nutrition. The primary outcome was reduction in depressive symptoms, measured using the Center for Epidemiological Studies–Depression (CES-D) scale. Data used in this study were collected at baseline and at the 1-year and 3-year follow-ups. Generalized estimating equations were used to examine the group differences at 1-year and 3-year follow-ups. Results Approximately half of the participants completed the assessment at 1-year (149/300, 49.7%) and 3-year (177/300, 59%) follow-ups. At 1-year follow-up, participants in the intervention group reported significant reduction in depressive symptoms compared with the control group (CES-D: from 23.9 to 18.1 in the intervention group vs from 24.3 to 23.3 in the control group; mean −4.79, SD 13.56; 95% CI −7.78 to −1.81; P=.002). At 3-year follow-up, between-group difference in CES-D remained statistically significant (from 23.9 to 20.5 in the intervention group vs from 24.3 to 24.4 in the control group; mean −3.63, SD 13.35; 95% CI −6.71 to −0.54; P=.02). No adverse events were reported during the 3-year follow-up period. Conclusions The mHealth intervention, Run4Love, significantly reduced depressive symptoms among people living with HIV, and the intervention effects were sustained at 1-year and 3-year follow-ups. Further research is needed to explore the mechanisms of the long-term effects of mHealth interventions such as Run4Love and to implement these effective interventions among people living with HIV. Trial Registration Chinese Clinical Trial Registry ChiCTR-IPR-17012606; https://trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR-IPR-17012606 International Registered Report Identifier (IRRID) RR2-10.2196/10274

Background: Older individuals have a high risk of morbidity and mortality due to COVID-19, and one of the most effective ways to prevent COVID-19 is vaccination. Little is known about older people’s willingness to receive a COVID-19 vaccine. Therefore, the objective of this study was to assess the acceptance of and factors influencing the intention to receive a COVID-19 vaccination among older adults in Shanghai, China. Methods: A cross-sectional study was conducted among older adults (≥60 years old) in Shanghai. Face-to-face interviews with a questionnaire were conducted in community health service centers, recording several parameters: demographic information, health-related factors; perceived likelihood, severity, and burden of COVID-19; perceived safety, effectiveness, necessity, and benefit of the COVID-19 vaccine, as well as their trust in the vaccine delivery system and doctors; willingness to receive a COVID-19 vaccination. Bivariate analysis between several survey items and the willingness to receive a COVID-19 vaccination was conducted using a chi-square test. Logistic regression was used to assess to what degree each variable affected the willingness to receive a COVID-19 vaccination. Results: Of the 1067 participants, 90.91% (970/1067) confirmed that they were willing to receive a COVID-19 vaccination. The participants were more likely to be willing to be vaccinated if they were immigrants (OR = 1.988, 95%CI = 1.062–3.717), had an education level of junior high school (OR = 2.724, 95%CI = 1.000–7.423) or high school or above (OR = 3.993, 95%CI = 1.576–10.119), and had a monthly income of CNY 3000–5000 (OR = 32.770, 95%CI = 1.144–6.711) or CNY >5000 (OR = 2.309, 95%CI = 1.003–5.319). The participants were also more likely to be willing to be vaccinated if they had received a pneumonia vaccination previously (OR = 2.138, 95%CI = 1.016–4.500), perceived the safety of the COVID-19 vaccine (OR = 1.508, 95%CI = 1.073–2.119), perceived the necessity of the COVID-19 vaccine (OR = 2.604, 95%CI = 1.946–3.484), or trusted the suggestions of doctors (OR = 1.706, 95%CI = 1.115–2.618). The participants were less likely to be willing to be vaccinated if they were aged ≥76 years (OR = 0.498, 95%CI = 0.264–0.939), reported a physical health condition of bad or below (OR = 0.229, 95% CI = 0.095–0.549), or were worried about the adverse effects of a COVID-19 vaccination (OR = 0.503, 95%CI = 0.364–0.695). Conclusions: Under the free vaccination policy for COVID-19, older adults have a high intention to be vaccinated to prevent COVID-19 in Shanghai, China. Widely publicizing the safety and necessity of COVID-19 vaccination is necessary.

BACKGROUND Emerging studies have shown the effectiveness of mobile health (mHealth) interventions on reducing depressive symptoms among people living with HIV (PLWH). Most of these studies only had short-term follow-up with limited data on long-term effects. OBJECTIVE The purpose of this study was to assess the long-term effects of a randomized controlled trial (RCT) called Run4Love on depressive symptoms among PLWH at 1- and 3-year follow-ups. METHODS A total of 300 PLWH with depressive symptoms were recruited and randomized to an intervention or a control group in Guangzhou, China from September 2017 to January 2018. The intervention group received a 3-month Run4Love program, including adapted evidence-based cognitive behavioral stress management (CBSM) courses and exercise promotion via WeChat, a popular social media app. The control group received usual care and a brochure on nutrition. The primary outcome was depressive symptoms measured by the Center for Epidemiological Studies-Depression (CES-D) scale. Data used in this study were collected at baseline, 1- and 3-year follow-ups. Generalized estimating equations (GEEs) were performed to examine the group differences at 1- and 3-year follow-ups. RESULTS About half of the participants completed the assessment at 1-year (49.7%, 149/300) and 3-year (59.0%, 177/300) follow-ups. At 1-year follow-up, participants in the intervention group reported significant reduction in depressive symptoms compared to the control group (CES-D: from 23.9 to 18.1 vs. from 24.3 to 23.3, mean=-4.79, 95%CI -7.78 to -1.81; P=0.0018). At 3-year follow-up, between-group difference in CES-D remained statistically significant (from 23.9 to 20.5 vs. from 24.3 to 24.4, mean=-3.63, 95%CI -6.71 to -0.54; P=0.022). No adverse events were reported during the 3-year follow up. CONCLUSIONS The mHealth intervention, Run4love, significantly reduced depressive symptoms among PLWH and the intervention effects were sustained at 1- and 3-year follow-ups. Further research is needed to explore the mechanisms of the long-term effects of mHealth interventions such as Run4Love and implement these effective interventions among PLWH. CLINICALTRIAL Chinese Clinical Trial Registry ChiCTR-IPR-17012606; http://www.chictr.org.cn/showproj.aspx?proj=21019 (Archived by WebCite at https://www.webcitation.org/78Bw2vouF) INTERNATIONAL REGISTERED REPORT RR2-10.2196/10274