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Abstract. We develop a multi-element generalized polynomial chaos (ME-gPC) method for arbitrary probability measures and apply it to solve ordinary and partial differential equations with stochastic inputs. Given a stochastic input with an arbitrary probability measure, its random space is decomposed into smaller elements. Subsequently, in each element a new random variable with respect to a conditional probability density function (PDF) is defined, and a set of orthogonal polynomials in terms of this random variable is constructed numerically. Then, the generalized polynomial chaos (gPC) method is implemented element-by-element. Numerical experiments show that the cost for the construction of orthogonal polynomials is negligible compared to the total time cost. Efficiency and convergence of ME-gPC are studied numerically by considering some commonly used random variables. ME-gPC provides an efficient and flexible approach to solving differential equations with random inputs, especially for problems related to long-term integration, large perturbation, and stochastic discontinuities.

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