Transforming synaptic input into action potential output is a fundamental function of neurons. The pattern of action potential output from principal cells of the mammalian hippocampus encodes spatial and nonspatial information, but the cellular and circuit mechanisms by which neurons transform their synaptic input into a given output are unknown. Using a combination of optical activation and cell type-specific pharmacogenetic silencing in vitro, we found that dendritic inhibition is the primary regulator of input-output transformations in mouse hippocampal CA1 pyramidal cells, and acts by gating the dendritic electrogenesis driving burst spiking. Dendrite-targeting interneurons are themselves modulated by interneurons targeting pyramidal cell somata, providing a synaptic substrate for tuning pyramidal cell output through interactions in the local inhibitory network. These results provide evidence for a division of labor in cortical circuits, where distinct computational functions are implemented by subtypes of local inhibitory neurons.

The current outbreak of COVID-19 is an unprecedented event in air transportation. This is probably the first time that global aviation contributed to the planet-wide spread of a pandemic, with casualties in over two hundred countries. As of August 23rd, 2020, the number of infected cases has topped 23 million, reportedly relating to more than 800,000 deaths worldwide. However, there is also a second side of the pandemic: it has led to an unmatched singularity in the global air transportation system. In what could be considered a highly uncoordinated, almost chaotic manner, countries have closed their borders, and people are reluctant/unable to travel due to country-specific lock-down measures. Accordingly, aviation is one of the industries that has been suffering most due to the consequences of the pandemic outbreak, despite probably being one of its largest initial drivers. In this study, we investigate the impact of COVID-19 on global air transportation at different scales, ranging from worldwide airport networks where airports are nodes and links between airports exist when direct flights exist, to international country networks where countries are contracted as nodes, and to domestic airport networks for representative countries/regions. We focus on the spatial-temporal evolutionary dynamics of COVID-19 in air transportation networks. Our study provides a comprehensive empirical analysis on the impact of the COVID-19 pandemic on aviation from a complex system perspective using network science tools.

Estimating, understanding, and improving the robustness of networks has many application areas such as bioinformatics, transportation, or computational linguistics. Accordingly, with the rise of network science for modeling complex systems, many methods for robustness estimation and network dismantling have been developed and applied to real-world problems. The state-of-the-art in this field is quite fuzzy, as results are published in various domain-specific venues and using different datasets. In this study, we report, to the best of our knowledge, on the analysis of the largest benchmark regarding network dismantling. We reimplemented and compared 13 competitors on 12 types of random networks, including ER, BA, and WS, with different network generation parameters. We find that network metrics, proposed more than 20 years ago, are often non-dominating competitors, while many recently proposed techniques perform well only on specific network types. Besides the solution quality, we also investigate the execution time. Moreover, we analyze the similarity of competitors, as induced by their node rankings. We compare and validate our results on real-world networks. Our study is aimed to be a reference for selecting a network dismantling method for a given network, considering accuracy requirements and run time constraints.

This paper aims to analyze and understand the impact of the corona virus disease (COVID-19) on aviation and also the role aviation played in the spread of COVID-19, by reviewing the recent scientific literature. We have collected 110 papers on the subject published in the year 2020 and grouped them according to their major application domain, leading to the following categories: Analysis of the global air transportation system during COVID-19, the impacts on the passenger-centric flight experience, and the long-term impacts on broad aviation. Based on the aggregated reported findings in the literature, this paper concludes with a set of recommendations for future scientific directions; hopefully helping aviation to prepare for a post-COVID-19 world.

A 30‐day experiment was performed to investigate the effects of bioflocs on water quality, and survival, growth and digestive enzyme activities of the white shrimp Litopenaeus vannamei. Altogether 28 shrimp (7.4 ± 0.1 g) were stocked in each 150 L tank. Two bioflocs treatments and one control were managed: ‘bioflocs 1’ and ‘bioflocs 2’ based on two different densities of the bioflocs, and clean water control without the bioflocs. Brown sugar was added to the bioflocs 1 and bioflocs 2 treatment tanks accounting for 28% and 80% of the shrimp feed respectively (corresponding to proximate C/N ratios of 10 and 14 in daily additions of organic matter respectively), so as to promote bioflocs production and approximately 14 mL L−1 in treatment bioflocs 1 and 20 mL L−1 in treatment bioflocs 2 were maintained from day 15. Monitoring of selected water quality parameters throughout the whole experiment period showed that all parameters remained within recommended levels for shrimp culture in the bioflocs treatments at zero‐water exchange, especially low total ammonia nitrogen and nitrite nitrogen levels. By the end of the experiment, shrimp survival rates were above 86%, with no significant differences (P > 0.05) among the three groups. Both weight gain rate and special growth rate tended to increase in the bioflocs treatments compared to those in the control. Meanwhile, the overall specific activities of protease, amylase, cellulase and lipase of the shrimp in the bioflocs treatments were all higher than those in the control; and for the specific activity of the same digestive enzyme, the differences between the bioflocs treatments and the control performed inconsistently among different organs: hepatopancreas, stomach and intestine. Present results suggest that the bioflocs can not only maintain favourable water quality conditions for shrimp culture and help shrimp grow well in zero‐water exchange culture systems, but may also have a positive effect on digestive enzyme activities of the shrimp.