An effective, template-free synthesis methodology has been developed for preparing mesoporous nitrogen-doped SrTiO 3 (meso-STON) using glycine as both a nitrogen source and a mesopore creator. The N-doping, large surface area and developed porosity endow meso-STON with excellent activity in visible-light-responsive photodegradation of organic dyes.The exceptional electro-optical properties and physicochemical stability of the perovskite SrTiO 3 (STO) give rise to its attractive performance in photocatalytic applications of solar power, including photocatalytic degradation of organic pollutants, water splitting and photoreduction of CO 2 .1-3 However, the intrinsic large bandgap energy (E g = 3.2 eV) of SrTiO 3 allows only the utilization of UV light, encompassing approximately 5.0% energy of the sunlight. 4 A variety of transition metals (TM) have been doped into a STO's crystal matrix in efforts to tune its electronic bandgap for harvesting visible light. 5,6Unfortunately, TM-doping can also bring about either phase impurity or fast recombination of photogenerated charge carriers. Nonmetal-doping represents another effective strategy to realize visible-light response.7-9 Indeed, it was found that N-doped SrTiO 3 (SrTiO 3Àx N x , STON) exhibited excellent photoreactivity and stability under visible-light irradiation. 10Mesoporous-structured photocatalysts are highly desirable in photocatalysis since their large specific surface area (SSA) and mesoporous channels greatly facilitate adsorption, diffusion and surface reaction of the reactants.11 STO perovskite belongs to the cubic crystal system, and typically has low SSA and poor porosity. Moreover, the porosity of STO could be further destroyed by the known processes of nitriding STO to STON. 5,12Although mesoporous STO has been prepared via templatedirected synthesis using various soft (e.g. surfactant or polymer 13 ) and hard (e.g. inorganic salts 14 ) templates, the synthesis of mesoporous STON has rarely been achieved.Here we report a novel, template-free synthesis methodology to prepare mesoporous STON using glycine as both a nitrogen source and a mesopore creator. Aqueous solution of glycine and Sr(NO 3 ) 2 was dropped into ethanol solution of titanium butoxide under stirring, followed by solvent evaporation and subsequent calcinations at 550 1C for 2 hours. The obtained STON was characterized by XRD, TEM, FTIR, UV-vis, and XPS techniques and used for the photodegradation of three refractory organic dyes under visible-light irradiation.Only a strong single peak appears in the small angle XRD pattern (Fig. 1) of the STON sample, suggesting that it possesses disordered wormlike mesopores. 15 The TEM image in Fig. 2A nicely confirms such mesoporosity. The HRTEM image inserted in Fig. 2A reveals that the walls of the mesopores are comprised of single crystal perovskite STON. The labelled lattice distances are consistent with those of (100) and (110) diffractions obtained from XRD tests (Fig. S1, ESIw). In contrast, the STO sample presents poor mesoporous featu...

NDRG2, a member of the N-Myc downstreamregulated gene family, was shown to be a putative tumor suppressor gene in glioblastoma and other cancers. Through a bioinformatic analysis, we found that NDRG2 protein contains an acyl carrier domain. In the current study, we therefore hypothesized that NDRG2 may play an important role in the regulation of histone acetylation. Treatment of U251 and U87 glioma cells with trichostatin A, an inhibitor of histone deacetylase, upregulated the expression of NDRG2 and acetylated forms of histones H3 and H4, reduced tumor cell viability and arrested the cell cycle at the G1/G0 phase. Overexpression of NDRG2 by transfecting glioma cells with adenovirus containing the NDRG2 gene upregulated the levels of acetylated forms of H3 and H4 whereas inhibition of NDRG2 expression by siRNA-mediated knockdown downregulated the level of histone acetylation. Furthermore, NDRG2 siRNA significantly reduced the level of histone acetylation induced by trichostatin A. Taken together, these data demonstrate that NDRG2 can regulate the level of histone acetylation to control glioma cell growth.

Keywords: jaringan sensor nirkabel (WSN), Ad hoc On-Demand Distance Vector (AODV), Power Balance AODV (PB-AODV), indikasi kekuatan sinyal diterima (RSSI) Abstract WSN (wireless sensor networks) is a kind of energy-constrained network, which has been widely

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