A lot of efforts have been devoted to investigating how agents can learn effectively and achieve coordination in multiagent systems. However, it is still challenging in large-scale multiagent settings due to the complex dynamics between the environment and agents and the explosion of state-action space. In this paper, we design a novel Dynamic Multiagent Curriculum Learning (DyMA-CL) to solve large-scale problems by starting from learning on a multiagent scenario with a small size and progressively increasing the number of agents. We propose three transfer mechanisms across curricula to accelerate the learning process. Moreover, due to the fact that the state dimension varies across curricula, and existing network structures cannot be applied in such a transfer setting since their network input sizes are fixed. Therefore, we design a novel network structure called Dynamic Agent-number Network (DyAN) to handle the dynamic size of the network input. Experimental results show that DyMA-CL using DyAN greatly improves the performance of large-scale multiagent learning compared with state-of-the-art deep reinforcement learning approaches. We also investigate the influence of three transfer mechanisms across curricula through extensive simulations.

Background Protein–protein interactions (PPIs) are of great importance in cellular systems of organisms, since they are the basis of cellular structure and function and many essential cellular processes are related to that. Most proteins perform their functions by interacting with other proteins, so predicting PPIs accurately is crucial for understanding cell physiology. Results Recently, graph convolutional networks (GCNs) have been proposed to capture the graph structure information and generate representations for nodes in the graph. In our paper, we use GCNs to learn the position information of proteins in the PPIs networks graph, which can reflect the properties of proteins to some extent. Combining amino acid sequence information and position information makes a stronger representation for protein, which improves the accuracy of PPIs prediction. Conclusion In previous research methods, most of them only used protein amino acid sequence as input information to make predictions, without considering the structural information of PPIs networks graph. We first time combine amino acid sequence information and position information to make representations for proteins. The experimental results indicate that our method has strong competitiveness compared with several sequence-based methods.

Three river basins, i.e., the Yangtze river, the Mississippi river and the Loire river, were presented as case studies to explore the association among atmospheric circulations, moisture exports and extreme precipitations in the mid-latitudes. The major moisture source regions in the tropics for the three river basins are first identified using the Tropical Moisture Exports (TMEs) dataset. The space-time characteristics of their respective moisture sources are presented. Then, the trajectory curve clustering analysis is applied to the TMEs tracks originating from the identified source regions during each basin's peak TMEs activity and flood seasons. Our results show that the moisture tracks for each basin can be categorized into 3 or 4 clusters with distinct spatial trajectory features. Our further analysis on these clustered trajectories reveals that the contributions of moisture release from different clusters are associated with their trajectory features and travel speeds. In order to understand the role of associated atmospheric steering, daily composites of the geopotential heights anomalies and the vertical integral of moisture flux anomalies from 7 days ahead to the extreme precipitation days (top 5%) are examined. The evolutions of the atmospheric circulation patterns and the moisture fluxes are both consistent with the TMEs tracks that contribute more moisture releases to the study regions. The findings imply that atmospheric steering plays an important role in the moisture transport and release, especially for the extreme precipitations. We also find that the association between TMEs moisture release and precipitation is nonlinear. The extreme precipitation is associated with high TMEs moisture release for all of the three study regions.

In E-commerce advertising, where product recommendations and product ads are presented to users simultaneously, the traditional setting is to display ads at fixed positions. However, under such a setting, the advertising system loses the flexibility to control the number and positions of ads, resulting in sub-optimal platform revenue and user experience. Consequently, major e-commerce platforms (e.g., Taobao.com) have begun to consider more flexible ways to display ads. In this paper, we investigate the problem of advertising with adaptive exposure: can we dynamically determine the number and positions of ads for each user visit under certain business constraints so that the platform revenue can be increased? More specifically, we consider two types of constraints: requestlevel constraint ensures user experience for each user visit, and platform-level constraint controls the overall platform monetization rate. We model this problem as a Constrained Markov Decision Process with per-state constraint (psCMDP) and propose a constrained two-level reinforcement learning approach to decompose the original problem into two relatively independent sub-problems. To accelerate policy learning, we also devise a constrained hindsight experience replay mechanism. Experimental evaluations on industry-scale real-world datasets demonstrate the merits of our approach in both obtaining higher revenue under the constraints and the effectiveness of the constrained hindsight experience replay mechanism.