Malignant hyperthermia (MH) is a lethal complication associated with general anesthesia characterized by sudden onset, rapid progression, and high mortality.We present two seemingly typical cases of intraoperative MH development, with details on perioperative assessment and rescue. Postoperative genetic test showed mutations in the ryanodine receptor type 1 gene.

Malignant hyperthermia (MH) is a lethal complication associated with general anesthesia characterized by sudden onset, rapid progression, and high mortality. Adequate preoperative assessment, attention to MH susceptibility, early identification of MH response, timely rescue, early use of dantrolene, and attention during cardiopulmonary bypass are necessary for comprehensive MH treatment.