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Background: This study explored the value of myocardial strain in the differential diagnosis of isolated left ventricular myocardial noncompaction (ILVNC) and dilated cardiomyopathy (DCM) using cardiac magnetic resonance (CMR) feature tracking technology. Methods: This retrospective analysis was performed on consecutive patients (25 with ILVNC, 30 with DCM, and 30 healthy controls) presenting to Shanxi Cardiovascular Hospital. All ILVNC patients met echocardiographic and CMR criteria for ventricular non-compaction. All patients with DCM met the 2016 American Heart Association and 2018 Chinese Medical Association Cardiovascular Branch diagnostic criteria. cvi42 software (Circle Cardiovascular Imaging) was used to measure radial, circumferential, and longitudinal strain (LS) globally and in segments of the left ventricle. Analysis of variance was used to compare strains among groups and among different segments within the same group. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy of different parameters in ILVNC and DCM.Results: Basal circumferential strain was lower in the DCM than in the ILVNC group (P=0.05). Both median and apical LS were lower in the ILVNC than in DCM group (P=0.02 and P=0.01, respectively).ROC curves showed that apical LS was the most effective in distinguishing ILVNC from DCM [area under the curve (AUC) 0.883; P<0.001; 95% CI: 0.850-0.977]. Comparing strains among different segments within the same group revealed that in DCM, the circumferential and LS of the apex were higher than those of the basal segment, which is consistent with the pattern in healthy controls; however, has no such regular pattern was seen in ILVNC.Conclusions: Myocardial strain parameters are of considerable value in the differential diagnosis of ILVNC and DCM. Differences in patterns between ILVNC and DCM can be sensitively identified, providing more comprehensive information for early clinical diagnosis.

The evaluation of cardiac magnetic resonance feature tracking may have great diagnostic value in hypertrophic cardiomyopathy and hypertension heart disease.To explore the diagnostic and clinical research value of cardiac magnetic resonance feature tracking in evaluation of myocardium deformation in patients with subclinical hypertrophic cardiomyopathy(SHCM)and subclinical hypertension heart disease(SHHD).CMR scans was performed on 1.5 T MR scanner in 33 patients with SHCM,31 patients with SHHD, and 27 controls(NS).The CMR image post-processing software was used to analyze the characteristics of routine cardiac function, different global and regional myocardial strain in each group.Analysis of variance (ANOVA) was used to compare age, blood pressure,heart rate,routine cardiac function,body mass index (BMI), as well as the strain between different segments within each of the three groups. If a significant difference was detected, a least significant difference (LSD) comparison was performed if there was a significant difference.The diagnostic efficacy of different parameters in differentiating SHHD from SHCM was evaluated through receiver operating characteristic (ROC) curve analysis, and determination of the best cutoff value.The routine cardiac function parameters were no statistically different among three groups (P＞0.05).There are statistical differences between the global myocardial strain parameters and the peak strain parameters of some segments,especially the basal segment, in each group (P＜0.05), and the Global radial peak strain(GRPS) can be used to distinguish SHCM from SHHD group (The area under the ROC curve was 0.885), which is the best diagnostic performance.Cardiac magnetic resonance feature tracking can detect left ventricular deformation in patients with SHCM and SHHD group.The abnormality of strain has important research value for its subclinical diagnosis and clinical evaluation.

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