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The objective of this study was to compare the safety and efficacy of endoscopic resection with surgical resection in the treatment of intermediate-risk gastric GISTs, and to further evaluate whether imatinib adjuvant treatment is necessary for resected intermediate-risk gastric GIST by ER. Methods: We retrospectively studied 128 cases for intermediate-risk gastric GISTs that were distributed in endoscopic (n=33) and surgical groups (n=95) at our center between December 2009 to July 2020. We statistically compared the clinical features, pathological reports, perioperative data, and long-term follow-up outcomes. Results: Compared with the surgery group, the endoscopy group was associated with smaller tumor size (2.4±1.0 vs 6.0±1.7cm, P<0.001), shorter operating time (67.3 ±36.5 vs 145.9±74.8min, P<0.001), fewer incidence of short term post-operative complications (3% vs 32.6%, P=0.002). Shorter post-operative hospital days (4.5±1.4 vs 8.5±2.4d, P<0.001), shorter gastric functional recovery time (P<0.001) and a lower overall medical cost of hospitalization (P<0.001) was detected in the endoscopy group. During the median 44.5 months follow-up period , there were no cases of recurrence, metastasis, and death in the endoscopy group. Among 128 patients, 68 accepted adjuvant therapy with imatinib after resection. It was observed that the OS of the adjuvant treatment group with imatinib was lower than that of the group without imatinib (P=0.033). Conclusions: Endoscopic resection for intermediate-risk gastric GIST is a feasible and safe method. And there is no significant benefit for patients with intermediate-risk gastric GIST to accept imatinib adjuvant treatment after ER.

Physics application practice is of great significance to the application of Physics and the cultivation of basic scientific research talents. With the continuous improvement of technology value cognition in the basic industry of China, the improvement of manufacturing industry competitiveness and the realization of innovation are inseparable from the participation of physical application technology. However, according to the results of industry research in recent years, the contribution rate of university Physics to society in China is far from expected, and there is still a lot to improve in the teaching of university application technologies and application practice abilities, which should focus on the future teaching. With the continuous exploration of Chinese computer education technology and data-base teaching technology, the teaching methods in colleges and universities have been greatly changed. According to the research, the current rate of online reading habits and communication habits of college students in China is up to about 67.9%. The demands of students’ independent growth and the needs for society comprehensive talents make college Physics undertake more training responsibilities and ability teaching tasks. As an important medium of college teaching, the development and application level of computer-aided system has a certain impact on the teaching effect of college Physics. At present, the CAI system with multimedia courseware as the core couldn’t meet the needs of students’ study. Therefore, it is necessary to design and deal with the CAI System in a more diversified way. Because of its high abstraction, theory and comprehensiveness, the past teaching practice of college Physics is difficult to achieve high results. Therefore, based on the computer aided system, this paper explores the reform direction and feasibility realization mode of applied technology college Physics teaching.