Optomagnonics is a good platform for the interplay of radio frequency and optical signals, which are the primary communication carriers in the present day. On the basis of optomagnonics, we provide a multi-scale method for analyzing its behavior, including frequency comb and RoF chaotic synchronization at the microwave scale. Adjusting the pump light intensity permits the transition of RoF signals between harmonics, frequency combs, and chaotic movements. The dual optomagnonical device enables the synchronization of RoF signals between different cavities. Our study will contribute to the use of multiscale electromagnetic wave coupling in both conventional and quantum information applications.

BackgroundLiddle syndrome is a form of monogenic hypertension caused by mutations in the three homologous subunits of the epithelial sodium channels (ENaCs), α, β, and γ. It is characterized by early-onset refractory hypertension, hypokalemia, low renin activity, and hypoaldosteronism. In this study, we report a novel frame-shift mutation in SCNN1B responsible for Liddle syndrome in a Chinese family.MethodsDNA samples were collected from all participants. Whole-exome sequencing was performed in the proband to detect possible causative variants. Sanger sequencing was then conducted in the other family members to verify the candidate variant, and in 100 patients with hypertension and 100 normotensive controls to exclude population genetic polymorphism.ResultsWe identified a novel frame-shift mutation (c.1691_1693delinsG) in SCNN1B that was responsible for Liddle syndrome in this family. This mutation leads to the substitution of Arg in place of Gln at codon site 564 and generates a new stop codon at 592, influencing the crucial PY motif and resulting in reduced inactivation of the ENaCs. Aside from the proband, eight family members carried the mutation. Intra-familial phenotypic heterogeneity was observed in the blood pressure and serum potassium levels. Amiloride therapy combined with a low sodium diet is effective to alleviate the symptoms of patients with Liddle syndrome.Conclusionc.1691_1693delinsG, a novel frame-shift mutation in the β subunit of ENaC, was identified in a Chinese family with Liddle syndrome by whole-exome sequencing. Phenotypic heterogeneity can make diagnosis of Liddle syndrome difficult on the basis of clinical or biochemical characteristics alone. Genetic analysis is a useful tool allowing timely and accurate diagnosis of Liddle syndrome and playing a guiding role in precise treatment of the disease.

Hermiticity is the fundamental property of the physical systems, for which it should obey the laws of energy conservation and time-reversal symmetry. Parity-time symmetry is introduced to study the non-Hermitian system with real energy spectra. Considering the coupling dissipation of the practical system, there would be phase-related terms on the non-diagonal elements of the Hermitian matrix. Here in this work, we present a coupled circuit model of the system and investigate the dynamics of parity-time-anyonic Hamiltonian related to an arbitrary phase of the system. We find that parity-time symmetry can be achieved under the tunable phases in the quasi-parity-time symmetric circuit system.

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